The potential applications of artificial intelligence in drug discovery and development

Title:

The potential applications of artificial intelligence in drug discovery and development

Creator:

Farghali, Hassan, Kutinová Canová, Nikolina, and Arora, Mahak

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e8e9115a-9568-41f7-9201-7ec6a28f861f
uuid:e8e9115a-9568-41f7-9201-7ec6a28f861f
doi:10.33549/physiolres.934765

Subject:

artificial intelligence, computer-assisted drug discovery, drug repositioning, machine learning, and DSP-1181

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Development of a new dug is a very lengthy and highly expensive process since only preclinical, pharmacokinetic, pharmacodynamic and toxicological studies include a multiple of in silico, in vitro, in vivo experimentations that traditionally last several years. In the present review, we briefly report some examples that demonstrate the power of the computer-assisted drug discovery process with some examples that are published and revealing the successful applications of artificial intelligence (AI) technology on this vivid area. Besides, we address the situation of drug repositioning (repurposing) in clinical applications. Yet few success stories in this regard that provide us with a clear evidence that AI will reveal its great potential in accelerating effective new drug finding. AI accelerates drug repurposing and AI approaches are altogether necessary and inevitable tools in new medicine development. In spite of the fact that AI in drug development is still in its infancy, the advancements in AI and machine-learning (ML) algorithms have an unprecedented potential. The AI/ML solutions driven by pharmaceutical scientists, computer scientists, statisticians, physicians and others are increasingly working together in the processes of drug development and are adopting AI-based technologies for the rapid discovery of medicines. AI approaches, coupled with big data, are expected to substantially improve the effectiveness of drug repurposing and finding new drugs for various complex human diseases.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S715-S722

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 4

Harvested from:

CDK

Metadata only:

false