Subconvulsive dose of kainic acid transiently increases the locomotor activity of adult wistar rats

Title:

Subconvulsive dose of kainic acid transiently increases the locomotor activity of adult wistar rats

Creator:

Vladimír Riljak, Dana Marešová, Pokorný, J., and Kateřina Jandová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:e9fb38f2-6faf-4121-aad2-3b9a987a9b1c
uuid:e9fb38f2-6faf-4121-aad2-3b9a987a9b1c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, kainic acid, laboras, behavior, wistar rat, locomotor activity, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Kainic acid (KA) is a potent neurotoxic substance valuable in research of temporal lobe epilepsy. We tested how subconvulsive dose of KA influences spontaneous behavior of adult Wistar rats. Animals were treated with 5 mg/kg of KA and tested in Laboras open field test for one hour in order to evaluate various behavioral parameters. Week after the KA treatment animals were tested again in Laboras open field test. Finally, rat’s brains were sliced and stained with Fluoro-Jade B to detect possible neuronal degeneration. Treatment with KA increased the time spent by locomotion (p<0.01), exploratory rearing (p<0.05) and animals traveled longer distance (p<0.01). These parameters tended to increase thirty minutes after KA administration. Week after the treatment we did not found differences in any measured behavioral parameter. Histology in terms of Fluoro-Jade B staining did not reveal any obvious neuronal damage in hippocampus. These results demonstrate that subconvulsive KA dose changes the behavioral parameters only transiently. Clarification of timing of the KA induced changes may contribute to understand mutual relationship between non-convulsive seizures and behavioral/cognitive consequences., V. Riljak, D. Marešová, J. Pokorný, K. Jandová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:2

Harvested from:

CDK

Metadata only:

false