Effect of methylprednisolone on experimental brain edema in magnetic resonance imaging

Title:

Effect of methylprednisolone on experimental brain edema in magnetic resonance imaging

Creator:

Kozler, Petr, Herynek, Vít, Marešová, Dana, Perez, Pablo D, Šefc, Luděk, and Pokorný, Jaroslav

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ea1290e9-f0fa-4325-be13-828bf755122e
uuid:ea1290e9-f0fa-4325-be13-828bf755122e
issn:0862-8408
doi:10.33549/physiolres.934460

Subject:

fyziologie, physiology, methylprednisolone, magnetic resonance imaging, water intoxication, cytotoxic edema, vasogenic edema, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Magnetic resonance imaging has been used for evaluating of a brain edema in experimental animals to assess cytotoxic and vasogenic edema by the apparent diffusion coefficient (ADC) and T2 imaging. This paper brings information about the effectiveness of methylprednisolone (MP) on experimental brain edema. A total of 24 rats were divided into three groups of 8 animals each. Rats with cytotoxic/intracellular brain edema induced by water intoxication were assigned to the group WI. These rats also served as the additional control group CG when measured before the induction of edema. A third group (WIMP) was intraperitoneally administered with methylprednisolone 100 mg/kg during water intoxication treatment. The group WI+MP was injected with methylprednisolone 50 mg/kg into the carotid artery within two hours after the water intoxication treatment. We evaluated the results in four groups. Two control groups (CG, WI) and two experimental groups (WIMP, WI+MP). Rats were subjected to MR scanning 24 h after edema induction. We observed significantly increased ADC values in group WI in both evaluated areas - cortex and hippocampus, which proved the occurrence of experimental vasogenic edema, while ADC values in groups WIMP and WI+MP were not increased, indicating that the experimental edema was not developed and thus confirming the protective effect of MP., Petr Kozler, Vít Herynek, Dana Marešová, Pablo D. Perez, Luděk Šefc, Jaroslav Pokorný., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

919-926

Source:

Physiological research | 2020 Volume:69 | Number:5

Harvested from:

CDK

Metadata only:

false