Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation

Title:

Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation

Creator:

Nishiyama, Y., Kataoka, T., Teraoka, J., Sakoda, A., Hiroyuki Tanaka, Ishimori, Y., Mitsunobu, F., Taguchi, T., and Yamaoka, K.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ea3c5e38-7a7e-4c71-b26e-1faf6ed09226
uuid:ea3c5e38-7a7e-4c71-b26e-1faf6ed09226

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, radon inhalation, antioxidative function, streptozotocin, type- 1 diabetes, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

We examined the protective effect of radon inhalation on streptozotocin (STZ)-induced type-1 diabetes in mice. Mice inhaled radon at concentrations of 1000, 2500, and 5500 Bq/m3 for 24 hours before STZ administration. STZ administration induced characteristics of type-1 diabetes such as hyperglycemia and hypoinsulinemia; however, radon inhalation at doses of 1000 and 5500 Bq/m3 significantly suppressed the elevation of blood glucose in diabetic mice. Serum insulin was significantly higher in mice pre-treated with radon at a dose of 1000 Bq/m3 than in mice treated with a sham. In addition, superoxide dismutase activities and total glutathione contents were significantly higher and lipid peroxide was significantly lower in mice pre-treated with radon at doses of 1000 and 5500 Bq/m3 than in mice treated with a sham. These results were consistent with the result that radon inhalation at 1000 and 5500 Bq/m3 suppressed hyperglycemia. These findings suggested that radon inhalation suppressed STZ-induced type-1 diabetes through the enhancement of antioxidative functions in the pancreas., Y. Nishiyama, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:1

Harvested from:

CDK

Metadata only:

false