Transformation of blood monocytes to multinucleated giant cells in vitro: are there any differences between malignant and nonmalignant states ?

Title:

Transformation of blood monocytes to multinucleated giant cells in vitro: are there any differences between malignant and nonmalignant states ?

Creator:

Munzarová, M. and Zemanová, D.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ea6362a3-14b9-4f14-81a6-619ecf6249b4
uuid:ea6362a3-14b9-4f14-81a6-619ecf6249b4

Subject:

cell fusion, monocytes, macrophages, melanoma, breast cancer, and multinucleated giant cells

Type:

article, model:article, and TEXT

Description:

Blood monocytes (BMs) from 139 subjects (70 malignant melanoma patients, 31 breast cancer patients, 38 healthy controls) were cultured for at least 7 days. The formation of multinucleated giant cells (MGCs), which was checked during the whole time of culture, was observed in all cases. By the seventh day MGCs represented 25-50 % and during the second and third month more than 90% of all cells. Lymphokines and/or concanavalin A stimulation (16-34 cases respectively) of BMs was performed as well. This stimulation greatly accelerated MGC formation. There were no differences either in spontaneous or in stimulated fusion between the different groups compared.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1992 Volume:41 | Number:3

Harvested from:

CDK

Metadata only:

false