Effect of serotonin on small intestinal contractility in healthy volunteers

Title:

Effect of serotonin on small intestinal contractility in healthy volunteers

Creator:

Hansen, Mark Berner, Arif, F., Gregersen, H., Bruusgaard, H., and Wallin, L.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ec8e5af6-4475-45c0-882e-ec2cb2a52053
uuid:ec8e5af6-4475-45c0-882e-ec2cb2a52053
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, člověk, gastrointestinální motilita, physiology, human beings, gastrointestinal motility, blood levels, 5-hydroxytryptamine, migrating motor complex, serotonin, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The physiological significance of serotonin released into the intestinal lumen for the regulation of motility is unknown in humans. The aim of this study was to evaluate the effect of serotonin infused into the lumen of the gastric antrum, duodenum or the jejunum, on antro-duodeno-jejunal contractility in healthy human volunteers. Manometric recordings were obtained and the effects of either a standard meal, continuous intravenous infusion of serotonin (20 nmol/kg/min) or intraluminal bolus infusions of graded doses of serotonin (2.5, 25 or 250 nmol) were compared. In addition, platelet-depleted plasma levels of serotonin, blood pressure, heart rate and electrocardiogram were evaluated. All subjects showed similar results. Intravenous serotonin increased migrating motor complex phase III frequency 3-fold and migrating velocity 2-fold. Intraluminal infusion of serotonin did not change contractile activity. Platelet-depleted-plasma levels of serotonin increased 2-fold following both intravenous and high doses of intraluminal infusions of serotonin. All subjects reported minor short-lived adverse effects following intravenous serotonin stimulation, while only half of the subjects reported minor short-lived adverse effects following intraluminal serotonin stimulations. We conclude that exogenous serotonin in the lumen of the upper part of the small intestine does not seem to change antro-duodeno-jejunal contractility significantly in healthy adult volunteers., M. B. Hansen, F. Arif, H. Gregersen, H. Bruusgaard, L. Wallin., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:1

Harvested from:

CDK

Metadata only:

false