Repetitive transcranial magnetic stimulation (rTMS) modulates hippocampal structural synaptic plasticity in rats

Title:

Repetitive transcranial magnetic stimulation (rTMS) modulates hippocampal structural synaptic plasticity in rats

Creator:

Li, Y., Li, L., and Pan, W.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ee340a04-71fb-44d1-9d19-125cbdda1191
uuid:ee340a04-71fb-44d1-9d19-125cbdda1191
doi:10.33549/physiolres.933772

Subject:

transcranial magnetic stimulation, synaptic plasticity, and CaMKII

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Repetitive transcranial magnetic stimulation (rTMS) was shown to have therapeutic potential for some neurological and psychiatric disorders. Previous studies reported that low-frequency rTMS (≤1 Hz) affected synaptic plasticity in rats, however, there were few investigations to examine the possible effects of rTMS on structural synaptic plasticity changes in rats, which included the effects on synaptic morphology in the hippocampus, synaptic protein markers and Ca2+/calmodulin-dependent protein II (CaMKII). Sprague-Dawley rats were subject to 500 pulses of 0.5 Hz rTMS for 15 days, or sham stimulation. After last stimulation, transmission electron microscope (TEM) and real-time PCR were used to determine the effects of rTMS on synaptic plasticity. Results showed that rTMS could cause the change of structural synaptic plasticity, increase the expression of synaptic protein markers: synaptophysin (SYN) and increase the expression of CaMKII, relative to normal rats. suggesting a modulatory effect of chronic rTMS on synaptic plasticity that may be attributed to the increased expression of CaMKII in rats.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2019 Volume:68 | Number:1

Harvested from:

CDK

Metadata only:

false