Differences in bisphenol A and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility

Title:

Differences in bisphenol A and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility

Creator:

Vítků, J., Sosvorová, L., Chlupacova, T., Richard Hampl, Hill, M., Vladimír Sobotka, Jiří Heráček, Marie Bičíková, and Luboslav Stárka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:eec6d2ca-8095-4d0f-96ea-44f03af504fb
uuid:eec6d2ca-8095-4d0f-96ea-44f03af504fb
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, bisfenol A, krevní plazma, neplodnost mužů, bisphenol A, blood plasma, male infertility, estrone, estradiol, estriol, seminal fluid, seminal plasma, LC-MS, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The general population is potentially exposed to many chemicals that can affect the endocrine system. These substances are called endocrine disruptors (EDs), and among them bisphenol A (BPA) is one of the most widely used and well studied. Nonetheless, there are still no data on simultaneous measurements of various EDs along with steroids directly in the seminal fluid, where deleterious effects of EDs on spermatogenesis and steroidogenesis are assumed. We determined levels of BPA and 3 estrogens using LC-MS/MS in the plasma and seminal plasma of 174 men with different degrees of infertility. These men were divided according their spermiogram values into 4 groups: (1) healthy men, and (2) slightly, (3) moderate, and (4) severely infertile men. Estradiol levels differed across the groups and body fluids. Slightly infertile men have significantly higher BPA plasma and seminal plasma levels in comparison with healthy men (p<0.05 and p<0.01, respectively). Furthermore, seminal BPA, but not plasma BPA, was negatively associated with sperm concentration and total sperm count (-0.27; p<0.001 and -0.24; p<0.01, respectively). These findings point to the importance of seminal plasma in BPA research. Overall, a disruption of estrogen metabolism was observed together with a weak but significant impact of BPA on sperm count and concentration., J. Vitku, L. Sosvorova, T. Chlupacova, R. Hampl, M. Hill, V. Sobotka, J. Heracek, M. Bicikova, L. Starka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false