Oral administration of polyphenolic compounds from Cognac decreases ADP-induced platelet aggregation and reduces chronotropic effect of isoprenaline in rats

Title:

Oral administration of polyphenolic compounds from Cognac decreases ADP-induced platelet aggregation and reduces chronotropic effect of isoprenaline in rats

Creator:

Carusio, N., Wangensteen, R., Filippelli, A., and Ramaroson Andriantsitohaina

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:efdddbe1-1f11-47a0-8f6c-f1f015c28f9c
uuid:efdddbe1-1f11-47a0-8f6c-f1f015c28f9c
issn:0862-8408

Subject:

Experimentální medicína, fyziologie, polyfenoly, trombocyty, oxid dusnatý, physiology, polyphenols, thrombocytes, nitric oxide, Cognac, platelet aggregation, isoprenaline, 14, and 616-092

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

This study sought to evaluate whether consumption of polyphenol extract from Cognac (CPC) modulates platelet activation and cardiovascular reactivity in rats. Male Wistar rats were treated daily for 4 weeks by intra-gastric gavage receiving CPC at 80 mg/kg/day or vehicle (5 % glucose). Platelet adhesion and aggregation in response to different activators were assessed. Cardiac and vascular reactivity in response to various agonists as well as NO measurement by electron paramagnetic resonance technique were investigated in isolated heart and thoracic aorta. Oral administration of CPC decreased platelet aggregation induced by ADP but not by collagen. CPC did not affect adhesion to collagen. The chronotropic but not the inotropic response to isoprenaline was reduced without alteration of NO production in hearts from CPC-treated rats. CPC treatment did not affect ex vivo relaxation to acetylcholine nor NO content of rat aorta. CPC did not significantly alter the response to phenylephrine in aorta despite the participation of endothelial vasoconstrictor products. In summary, chronic treatment with CPC has no impact on ex vivo vascular and cardiac reactivity; however, it reduced heart work and platelet aggregation. These data suggest the existence of compounds in Cognac that may decrease the risk of coronary thrombosis and protect against some cardiac diseases., N. Carusio, R. Wangensteen, A. Filippelli, R. Andriantsitohaina., and Obsahuje bibliiografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:4

Harvested from:

CDK

Metadata only:

false