Pharmacogenetic analysis of captopril effects on blood pressure: possible role of the Ednrb (endothelin receptor type B) candidate gene

Title:

Pharmacogenetic analysis of captopril effects on blood pressure: possible role of the Ednrb (endothelin receptor type B) candidate gene

Creator:

Josef Zicha, Zdena Dobešová, Václav Zídek, Šilhavý, J., Miroslava Šimáková, Petr Mlejnek, Ivana Vaněčková, Jaroslav Kuneš, and Michal Pravenec

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f022170d-24c9-4df6-9869-de031a612393
uuid:f022170d-24c9-4df6-9869-de031a612393

Subject:

Fyziologie člověka a srovnávací fyziologie, krevní tlak, genetika, blood pressure, genetics, captopril, Ednrb gene, spontaneously hypertensive rat, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The objective of the current study was to search for genetic determinants associated with antihypertensive effects of angiotensin-converting enzyme (ACE) inhibitor captopril. Linkage and correlation analyses of captopril-induced effects on blood pressure (BP) with renal transc riptome were performed in the BXH/HXB recombinant inbred (RI) strains derived from spontaneously hypertensive rat (SHR) and Brown Norway (BN-Lx) progenitors. Variability of blood pressure lowering effects of captopril among RI strains was continuous suggesting a polygenic mode of inheritance. Linkage analysis of captopril- induced BP effects revealed a significant quantitative trait locus (QTL) on chromosome 15. This QTL colocalized with cis regulated expression QTL (eQTL) for the Ednrb (endothelin receptor type B) gene in the kidney (SHR allele was associated with increased renal expression) and renal expression of Ednrb correlated with captopril-induced BP effects. These results suggest that blood pressure lowering effects of ACE inhibitor captopril may be modulated by the variants at the Ednrb locus., J. Zicha ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:2

Harvested from:

CDK

Metadata only:

false