Lithium / pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent

Title:

Lithium / pilocarpine status epilepticus-induced neuropathology of piriform cortex and adjoining structures in rats is age-dependent

Creator:

Rastislav Druga, Hana Kubová, Suchomelová, L, and Renata Haugvicová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f253bb57-a1f7-402c-97d0-dde9d86694fa
uuid:f253bb57-a1f7-402c-97d0-dde9d86694fa
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, epilepsie, epilepsy, piriform cortex, endopiriform nucleus, basal telencephalon, pilocarpine, parvalbumin, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Distribution of LiCl/pilocarpine status epilepticus-induced neuronal damage was studied in the piriform cortex and in adjoining structures in 12-day-old, 25-day-old and adult rats. No distinct structural and neuronal alterations were detected in the basal telencephalon in 12-day-old rats surviving status epilepticus (SE) for one week or two months. In 25-day-old rats a decrease in Nissl staining was evident. There was also cell loss and gliosis in the caudal 2/3 of the piriform cortex, in the superficial amygdaloid nuclei, in the dorsal and ventral endopiriform nucleus and in the rostrolateral part of the entorhinal cortical area. In adult animals, the topography of neuropathological changes in the basal telencephalon was comparable to those in 25-day-old rats. The damage in the caudal 2/3 or caudal half of the piriform cortex in adult rats with survival times one week or two months was characterized by a marked loss of neurons and striking glial infiltration. The thickness of the piriform cortex and superficial amygdaloid nuclei was significantly reduced. In 25-day-old and in adult animals the sublayer IIb and layer III of the piriform cortex was more affected, while sublayer IIa was less damaged. Parvalbumin (PV) immunocytochemistry revealed a significant decrease in the number of PV-immunoreactive neurons in the rostral piriform cortex and in the dorsal claustrum in animals surviving for two months., R. Druga, H. Kubová, L. Suchomelová, R. Haugvicová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:2

Harvested from:

CDK

Metadata only:

false