Apolipoprotein AV Variants Do Not Affect C-Reactive Protein Levels in Caucasian Males

Title:

Apolipoprotein AV Variants Do Not Affect C-Reactive Protein Levels in Caucasian Males

Creator:

Hubáček, J.A., Škodová, Z., Lánská, V., Stávek, P., Adámková, V., and Poledne, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f4e25fbd-9ce0-4785-93ba-950339782958
uuid:f4e25fbd-9ce0-4785-93ba-950339782958

Subject:

Apolipoprotein AV, Polymorphism, Genetics, Triglycerides, Myocardial infarction, and CRP

Type:

article, model:article, and TEXT

Description:

The important role of APOAV gene variants in determination of plasma triglyceride levels has been shown in many population studies. Recently, an influence of APOAV T-1131>C polymorphism on C-reactive protein (CRP) in young Korean males has been reported. We have therefore analyzed a putative association between T-1131>C, Ser19>Trp and Val153>Met APOAV variants (PCR and restriction analysis) and CRP concentrations in 1119 Caucasian males, aged between 28 and 67 years (49.2±10.8 years). The frequency of C allele carriers was lower in Caucasians than in Koreans (15.5 % vs. 46.2 %). CRP levels did not differ between T/T homozygotes (n=946, 1.61±2.05 mg/l) and carriers of the C allele (n=173, 1.67±1.95 mg/l). Thus, in contrast to Korean males, T-1131>C APOAV variant has no effect on plasma concentrations of CRP in a large group of Caucasian males. Other APOAV variants (Ser19>Trp and Val153>Met) did not also influence plasma concentrations of CRP. APOAV variants are unlikely to be an important genetic determinant of plasma CRP concentrations in Caucasian males.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2005 Volume:54 | Number:6

Harvested from:

CDK

Metadata only:

false