Brain-derived neurotrophic factor treatment increases the skeletal muscle glucose transporter 4 protein expression in mice

Title:

Brain-derived neurotrophic factor treatment increases the skeletal muscle glucose transporter 4 protein expression in mice

Creator:

Suwa, M., Yamamoto, K.-I., Nakano, H., Sasaki, H., Radak, Z., and Kumagai, S.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f8332535-87fe-464c-84b3-15237fa5203c
uuid:f8332535-87fe-464c-84b3-15237fa5203c

Subject:

Fyziologie člověka a srovnávací fyziologie, svaly, muscles, BDNF, GLUT4, hypophagia, skeletal muscle, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The purpose of the present study was to investigate whether peripheral brain-derived neurotrophic factor (BDNF) treatment induced metabolic adaptations in mouse skeletal muscle. BDNF (20 mg/kg/day) was injected subcutaneously for successive 14 days. BDNF treatment significantly reduced the total food intake and inhibited the weight gain in comparison to the control group. The glucose transporter 4 (GLUT4) protein expression in the gastrocnemius muscle was significantly increased by BDNF treatment in comparison to the control and pair-fed groups. Neither the oxidative nor the glycolytic enzyme activities in the gastrocnemius muscle changed after the BDNF treatment. These results suggest that the peripheral BDNF treatment promotes the skeletal muscle GLUT4 protein expression as well as hypophagia., M. Suwa ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:4

Harvested from:

CDK

Metadata only:

false