Testosterone modulates cardiomyocyte Ca2+ handling and contractile function

Title:

Testosterone modulates cardiomyocyte Ca2+ handling and contractile function

Creator:

Curl, C. L., Delbridge, L. M. D., Canny, B. J., and Wendt, I. R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f93f8863-3955-4149-8282-3e8959facbe2
uuid:f93f8863-3955-4149-8282-3e8959facbe2

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, testosteron, physiology, testosterone, cardiac myocyte, cardiac contractility, gonadectomy, intracellular calcium, isotonic shortening, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The extent to which sex differences in cardiac function may be attributed to the direct myocardial influence of testosterone is unclear. In this study the effects of gonadal testosterone withdrawal (GDX) and replacement (GDX+T) in rats, on cardiomyocyte shortening and intracellular Ca2+ handling was investigated (0.5 Hz, 25 oC). At all extracellular [Ca2+] tested (0.5-2.0 mM), the Ca2+ transient amplitude was significantly reduced (by ~ 50 %) in myocytes of GDX rats two weeks post- gonadectomy. The time course of Ca2+ transient decay was significantly prolonged in GDX myocytes (tau, 455±80 ms) compared with intact (279±23 ms) and GDX+T (277±19 ms). Maximum shortening of GDX myocytes was markedly reduced (by more than 60 %) and relaxation significantly delayed (by more than 35 %) compared with intact and GDX+T groups. Thus testosterone replacement completely reversed the cardiomyocyte hypocontractility induced by gonadectomy. These results provide direct evidence for a role of testosterone in regulating functional Ca2+ handling and contractility in the heart., C. L. Curl ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:2

Harvested from:

CDK

Metadata only:

false