The effect of pheochromocytoma treatment on subclinical inflammation and endocrine function of adipose tissue

Title:

The effect of pheochromocytoma treatment on subclinical inflammation and endocrine function of adipose tissue

Creator:

Lenka Bošanská, Ondřej Petrák, Tomáš Zelinka, Miloš Mráz, Jiří Widimský, and Martin Haluzík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f959228d-80ac-4acb-bc0a-1f77d275873c
uuid:f959228d-80ac-4acb-bc0a-1f77d275873c

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, feochromocytomy, záněty, leptin, physiology, pheochromocytoms, inflammations, body weight, adiponectin, resistin, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The aim of our study was to evaluate the influence of surgical removal of pheochromocytoma on the endocrine function of adipose tissue and subclinical inflammation as measured by circulating C-reactive protein (CRP) levels. Eighteen patients with newly diagnosed pheochromocytoma were included into study. Anthropometric measures, biochemical parameters, serum CRP, leptin, adiponectin and resistin levels were measured at the time of diagnosis and six months after surgical removal of pheochromocytoma. Surgical removal of pheochromocytoma significantly increased body weight, decreased both systolic and diastolic blood pressure, fasting blood glucose and glycated hemoglobin levels. Serum CRP levels were decreased by 50 % six months after surgical removal of pheochromocytoma (0.49±0.12 vs. 0.23±0.05 mg/l, p<0.05) despite a significant increase in body weight. Serum leptin, adiponectin and resistin levels were not affected by the surgery. We conclude that increased body weight in patients after surgical removal of pheochromocytoma is accompanied by an attenuation of subclinical inflammation probably due to catecholamine normalization. We failed to demonstrate an involvement of the changes in circulating leptin, adiponectin or resistin levels in this process., L. Bošanská ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:3

Harvested from:

CDK

Metadata only:

false