Metformin attenuates myocardium dicarbonyl stress induced by chronic hypertriglyceridemia

Title:

Metformin attenuates myocardium dicarbonyl stress induced by chronic hypertriglyceridemia

Creator:

Hana Malínská, Škop, V, Martin Haluzík, Ludmila Kazdová, Svoboda, P, Marková, I, and Trnovská, J

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f9e163ef-b1ec-4b41-b02f-7ade430e192a
uuid:f9e163ef-b1ec-4b41-b02f-7ade430e192a
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Hypertriglyceridemia, Dicarbonyl stress, Methylglyoxal, Glyoxalase, Metabolic syndrome, Metformin, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Reactive dicarbonyls stimulate production of advanced glycation endproducts, increase oxidative stress and inflammation and contribute to the development of vascular complications. We measured concentrations of dicarbonyls - methylglyoxal (MG), glyoxal (GL) and 3-deoxyglucosone (3-DG) - in the heart and kidney of a model of metabolic syndrome - hereditary hypertriglyceridemic rats (HHTg) and explored its modulation by metformin. Adult HHTg rats were fed a standard diet with or without metformin (300 mg/kg b.w.) and dicarbonyl levels and metabolic parameters were measured. HHTg rats had markedly elevated serum levels of triacylglycerols (p<0.001), FFA (p<0.01) and hepatic triacylglycerols (p<0.001) along with increased concentrations of reactive dicarbonyls in myocardium (MG: p<0.001; GL: p<0.01; 3-DG: p<0.01) and kidney cortex (MG: p<0.01). Metformin treatment significantly reduced reactive dicarbonyls in the myocardium (MG: p<0.05, GL: p<0.05, 3-DG: p<0.01) along with increase of myocardial concentrations of reduced glutathione (p˂0.01) and glyoxalase 1 mRNA expression (p˂0.05). Metformin did not have any significant effect on dicarbonyls, glutathione or on glyoxalase 1 expression in kidney cortex. Chronically elevated hypertriglyceridemia was associated with increased levels of dicarbonyls in heart and kidney. Beneficial effects of metformin on reactive dicarbonyls and glyoxalase in the heart could contribute to its cardioprotective effects., H. Malínská, V. Škop, J. Trnovská, I. Marková, P. Svoboda, L. Kazdová, M. Haluzik., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:2

Harvested from:

CDK

Metadata only:

false