Molecular assessment of kidney allografts: are we closer to a daily routine?

Title:

Molecular assessment of kidney allografts: are we closer to a daily routine?

Creator:

Trailin, Andriy , Hruba, Petra , and Viklicky , Ondrej

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:f9ea6c7d-fb98-4fb4-aa87-524b0cd741ae
uuid:f9ea6c7d-fb98-4fb4-aa87-524b0cd741ae
doi:10.33549/physiolres.934278

Subject:

kidney transplantation, gene expression, RT-qPCR, microarray, MMDx, and molecular microscope

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Kidney allograft pathology assessment has been traditionally based on clinical and histological criteria. Despite improvements in Banff histological classification, the diagnostics in particular cases is problematic reflecting a complex pathogenesis of graft injuries. With the advent of molecular techniques, polymerasechain reaction, oligo- and microarray technologies allowed to study molecular phenotypes of graft injuries, especially acute and chronic rejections. Moreover, development of the molecular microscope diagnostic system (MMDx) to assess kidney graft biopsies represents the first clinical application of a microarraybased method in transplantation. Whether MMDx may replace conventional pathology is the subject of ongoing research, however this platform is particularly useful in complex histological findings and may help clinicians to guide the therapy.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

215-226

Source:

Physiological research | 2020 Volume:69 | Number:2

Harvested from:

CDK

Metadata only:

false