Impaired post-irradiation survival of cyclooxygenase-2-deficient mice

Title:

Impaired post-irradiation survival of cyclooxygenase-2-deficient mice

Creator:

Michal Hofer, Zuzana Hoferová, Gruzdev, A, Dušek, L, and Martin Falk

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fb5ee338-6119-4cd8-9d92-920b7a6f6bcb
uuid:fb5ee338-6119-4cd8-9d92-920b7a6f6bcb
issn:0862-8408

Subject:

ionizující záření, ionizing radiation, cyclooxygenase-2, COX-2 knock-out mice, post-irradiation survival, post-irradiation inflammation, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of γ-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation., M. Hofer, Z. Hoferová, A. Gruzdev, L. Dušek, M. Falk., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:5

Harvested from:

CDK

Metadata only:

false