General anesthesia and electrocardiographic parameters in in vivo experiments involving rats

Title:

General anesthesia and electrocardiographic parameters in in vivo experiments involving rats

Creator:

Svorc, Pavol

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fc65c57b-2293-409d-b264-5cee6b43cd06
uuid:fc65c57b-2293-409d-b264-5cee6b43cd06
doi:10.33549/physiolres.934848

Subject:

ECG parameters, general anesthesia, sex, chronobiology, and rat

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

In in vivo cardiovascular or toxicological studies involving rat models, changes in selected electrocardiographic (ECG) parameters are monitored after various interventions to assess the origin and development of heart rhythm disorders. Each ECG parameter has diagnostic significance; as such, commonly evaluated ECG parameters, including heart rate, PR interval, P wave duration, P wave amplitude, QRS complex, QT and QTc interval duration, R wave and T wave amplitude, of rats under various types of general anesthesia were the focus of this study. Studies that performed in vivo cardiovascular or toxicological experiments in rats were retrieved from a search of the Web of Science database for articles published mainly between 2000 and 2021. In total, the search retrieved 123 articles. ECG parameters that were reported as baseline or control values were summarized and averages with ranges were calculated. It is important to be cautious when interpreting results and, in discussions addressing the mechanisms underlying a given type of arrhythmia, acknowledge that initial ECG parameters may already be affected to some extent by the general anesthesia as well as by sex and the time of day the experiments were performed. and autoři: Pavol Svorc, Pavol Svorc Jr

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

177-192

Source:

Physiological research | 2022 Volume:71 | Number:2

Harvested from:

CDK

Metadata only:

false