Upper airway cough syndrome in pathogenesis of chronic cough

Title:

Upper airway cough syndrome in pathogenesis of chronic cough

Creator:

Lucanska, Miroslava , Hajtman, Andrej , Calkovsky, Vladimir , Kunc, Peter , and Pecova, Renata

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fd98cfa5-b5c9-4219-a2cc-ea016a95d575
uuid:fd98cfa5-b5c9-4219-a2cc-ea016a95d575
doi:10.33549/physiolres.934400

Subject:

cough, chronic cough, and upper airway cough syndrome

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Cough is one of the most important defensive reflexes. However, extensive non- productive cough is a harmful mechanism leading to the damage of human airways. Cough is initiated by activation of vagal afferents in the airways. The site of their convergence is particularly the nucleus of the solitary tract (nTS). The secondorder neurons terminate in the pons, medulla and spinal cord and there is also the cortical and subcortical control of coughing. Upper airway cough syndrome (UACS) – previously postnasal drip syndrome - is one of the most common causes of chronic cough together with asthma and gastroesophageal reflux. The main mechanisms leading to cough in patients with nasal and sinus diseases are postnasal drip, direct irritation of nasal mucosa, inflammation in the lower airways, upper airway inflammation and the cough reflex sensitization. The cough demonstrated by UACS patients is probably due to hypersensitivity of the upper airways sensory nerve or lower airways sensory nerve, or a combination of both. Further studies are needed to clarify this mechanism.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S35-S42

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 1

Harvested from:

CDK

Metadata only:

false