Mitochondrial Uncoupling Proteins – Facts and Fantasies

Title:

Mitochondrial Uncoupling Proteins – Facts and Fantasies

Creator:

Ježek, p., Žáčková, M., Růžička, M., Škobisová, E., and Jabůrek, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fdc9d0f9-1207-48ba-926e-b16b4df6c54e
uuid:fdc9d0f9-1207-48ba-926e-b16b4df6c54e

Subject:

Mitochondria, Mitochondrial uncoupling, Uncoupling proteins, Fatty acids, and Reactive oxygen species

Type:

article, model:article, and TEXT

Description:

Instead of a comprehensive review, we describe the basic undisputed facts and a modest contribution of our group to the fascinating area of the research on mitochondrial uncoupling proteins. After defining the terms uncoupling, leak, protein-mediated uncoupling, we discuss the assumption that due to their low abundance the novel mitochondrial uncoupling proteins (UCP2 to UCP5) can provide only a mild uncoupling, i.e. can decrease the proton motive force by several mV only. Contrary to this, the highly thermogenic role of UCP1 in brown adipose tissue is not given only by its high content (~5 % of mitochondrial proteins) but also by the low ATP synthase content and high capacity respiratory chain. Fatty acid cycling mechanism as a plausible explanation for the protonophoretic function of all UCPs and some other mitochondrial carriers is described together with th e experiments supporting it. The phylogenesis of all UCPs, estimated UCP2 content in several tissues, and details of UCP2 activation are described on the basis of our experiments. Functional activation of UCP2 is proposed to decrease reactive oxygen species (ROS) production. Moreover, reaction products of lipoperoxidation such as cleaved hydroperoxy-fatty acids and hydroxy-fatty acid can activate UCP2 and promote feedback down-regulation of mitochondrial ROS production.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2004 Volume:53 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false