Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease

Title:

Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer’s disease

Creator:

Zakaria, R., Wan Yaacob, W. M. H., Othman, Z., Long, I., Ahmad, A. H., and Al-Rahbi, B.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fe750a9c-dcba-477b-8797-ab8275251a8f
uuid:fe750a9c-dcba-477b-8797-ab8275251a8f
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, Alzheimerova choroba, Alzheimer's disease, lipopolysaccharide, memory impairment, rats, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Alzheimer’s disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats’ response following LPS injection. Factors such as dose of LPS, route of administration, nature and duration of exposure as well as age and gender of animal used should be taken into account when designing a study using LPS-induced memory impairment as model for AD., R. Zakaria, W. M. H. Wan Yaacob, Z. Othman, I. Long, A. H. Ahmad, B. Al-Rahbi., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:4

Harvested from:

CDK

Metadata only:

false