Pentoxifylline-associated reduction of indomethacin-induced rat gastric mucosal injury is supported by decreased lipid peroxidation

Title:

Pentoxifylline-associated reduction of indomethacin-induced rat gastric mucosal injury is supported by decreased lipid peroxidation

Creator:

Šallingová, Z. and Kohút, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:fed2d563-f855-4eb9-84a1-35b1c5829c8a
uuid:fed2d563-f855-4eb9-84a1-35b1c5829c8a

Subject:

pentoxifylline, indomethacin, gastric lesions, activated neutrophils, lipid peroxidation, and rat

Type:

article, model:article, and TEXT

Description:

Pentoxifylline pretreatment protects rat gastric mucosa against indomethacin-induced damage. Lipid peroxidation after indomethacin treatment (determined as thiobarbituric acid reactants) was significantly reduced by a single dose of pentoxifylline. The same was true for pentoxifylline administration for 6 days. There is a relationship between reduced lipid peroxidation, decreased number of circulating activated neutrophils and diminished disposition for acute gastric mucosal lesions induced by indomethacin in pentoxifylline-pretreated rats.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1994 Volume:43 | Number:2

Harvested from:

CDK

Metadata only:

false