Lipoprotein(a) and its position among other risk factors of atherosclerosis

Title:

Lipoprotein(a) and its position among other risk factors of atherosclerosis

Creator:

Lukáš Zlatohlávek, Kateřina Zídková, Michal Vrablík, Theodor Haas, Martina Vaclová, Helena Svobodová, and Richard Češka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ff310dea-fc93-4a9d-9fc2-a6b3f4d974f6
uuid:ff310dea-fc93-4a9d-9fc2-a6b3f4d974f6
issn:0862-8408

Subject:

Experimentální medicína, fyziologie, lipoproteiny, ateroskleróza, ischemická choroba srdeční, physiology, lipoproteins, atherosclerosis, ischemic heart disease, lipoprotein(a), apolipoprotein(a), risk factor, gene polymorphisms, 14, and 616-092

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Lipoprotein(a) [Lp(a)] comprises of an LDL particle and apolipoprotein(a) [apo(a)] and its elevated levels are considered a risk factor for atherosclerosis. The aim of our study was to find out whether elevated Lp(a) levels are associated with increased risk of atherosclerosis in patients with multiple other risk factors. We further tested the association of three polymorphisms of the apo(a) gene promoter with Lp(a) levels. No significant correlation was detected between Lp(a) levels and lipid and clinical parameters tested. The study demonstrated a significantly (p=0.0219) elevated Lp(a) level (mean 28±35 mg/dl, median 0.14) in patients with coronary heart disease (CHD). In a group with premature CHD the correlation was not significant anymore. There was a significant correlation between polymorphic loci of the promoter region of apo(a) gene and Lp(a) levels (+93C>T, p=0.0166, STR, p<0.0001). Our study suggests that elevated Lp(a) level is an independent risk factor of CHD in carriers of other important CHD risk factors. Observed association of sequence variants of the promoter of apo(a) gene with Lp(a) levels is caused in part due to linkage to a restricted range of apo(a) gene length isoforms., L. Zlatohlávek, K, Zídková, M. Vrablík, T. Haas, M. Prusíková, H. Svobodová, R. Češka., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:5

Harvested from:

CDK

Metadata only:

false