A comparative study of reactive hyperemia in human forearm skin and muscle

Title:

A comparative study of reactive hyperemia in human forearm skin and muscle

Creator:

Addor, G., Delachaux, A., Dischl, B., Hayoz, D., Liauder, L., Waeber, B., and Feihl, Francois

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ffa97ad7-6647-4c20-aad5-002aa3303d1f
uuid:ffa97ad7-6647-4c20-aad5-002aa3303d1f
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, patologická fyziologie, ischemie, physiology, pathological physiology, ischemia, vasodilation, laser Doppler, strain gauge plethysmography, surrogate endpoint, acetylsalicylate, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Reactive hyperemia (RH) in forearm muscle or skin microcirculation has been considered as a surrogate endpoint in clinical studies of cardiovascular disea e. We evaluated two potential confounders that might limit such use of RH, namely laterality of measurement and intake of non-steroidal anti-inflammatory drugs (NSAIDS). Twenty-three young non-smoking healthy adults were enrolled. In Experiment 1 (n=16), the RH elicited by 3 min of ischemia was recorded in the muscle (strain gauge plethysmography, hand excluded) and skin (laser Doppler imaging) of both forearms. In Experiment 2 (n=7), RH was determined in the dominant forearm only, one hour following oral acetylsalicylic acid (1 g) or placebo. In Experiment 1, peak RH was identical in both forearms, and so were the corresponding durations of responses. RH lasted significantly less in muscle than in skin (p=0.003), a hitherto unrecognized fact. In the skin, acetylsalicylate reduced duration (43 vs. 57.4 s for placebo, p=0.03), without affecting the peak response. In muscle, duration tended to decrease with acetylsalicylate (21.4 vs. 26.0 s with placebo, p=0.06) and the peak increase in blood flow was blunted (27.2 vs. 32.4 ml/min/100 ml tissue with placebo, p=0.003). We conclude that, when using RH as a surrogate endpoint in studies of cardiovascular disease, a confounding by laterality of measurement need not be feared, but NSAIDS may have an influence, although perhaps not on the peak response in the skin., G. Addor, A. Delachaux, B. Dischl, D. Hayoz, L. Liaudet, B. Waeber, F. Feihl., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:5

Harvested from:

CDK

Metadata only:

false