Cryptosporidium parvum causes life-threatening diarrhoea in immunocompromized, especially AIDS patients and the efficiency of proposed anti-cryptosporidial therapies is limited or doubtful. An immunosuppressed adult rat model of C. parvum infection was developed for screening molecules candidate for curative and preventive activity in human cryptosporidiosis. Among 31 drugs tested, lasalocid (2-10 mg/kg/24 h), and sinefungin (2-10 mg/kg/24 h), exhibited some activity against C. parvum infection. Oral sinefungin therapy resulted in a dose related suppression of oocysts shedding, which correlated with oocyst disappearance from ileum sections and was also efficient in preventing infection. Relapses were observed after discontinuation of curative sinefungin therapy, which suggests that the biliary tract, a major location and parasite reservoir which sustains persisting infection, was not cleared of parasites by the drug. Improved therapeutic procedures with sinefungin (or analogues) will result from current pharmacological studies.
The article analyses the most current myths regarding the sexual harassment in the Czech Republic. Specifically the author examines firstly the myth of non-existence and insignificancy which does not respect its latent nature; secondly she speaks about the myth of subjectivity and selfhood which denies the role of symbolic power and existence of unequal relations between men and women. Thirdly she identifies the myth of irrelevancy and impossibility to define the limits that denies equal moral value of all people; and finally she discusses the myth of malfeasance that denies possible serious harm caused to victims, the most frequently women. These myths are identified on the basis of qualitative analysis of focus groups with representatives of labour union. The author aims to confute these mentioned myths that contaminate the representation of the phenomenon of sexual harassment in the public discourse in the Czech Republic. For defence of significance of sexual harassment she elaborates the parallel with domestic violence and highlights common tendency to deny these gender based inequalities and oppression on the basis of the idea of ''natural sex relations''.
The kinetics of Ig-positive cell populations in carp tissues was followed during an infection with the gut dwelling coc-cidian Goussia carpelli Léger et Stankovich, 1921. In cell suspensions of the anterior and posterior sections of the intestine, the proportion of Ig-positive cells increased with the development of the coccidia and peaked during oocyst formation at day 15 post exposure. These results suggest a reaction of the local mucosal immune system. In cell suspensions of pronephros the proportion of Ig-positive cells increased as well, indicating that a systemic immune response was also induced against this intestinal cocci-dian parasite of carp.