An immunosuppressed rat model for evaluation of anti-Cryptosporidium activity of sinefungin

Title:

An immunosuppressed rat model for evaluation of anti-Cryptosporidium activity of sinefungin

Creator:

Brasseur, P., Favennec, L., Leméteil, D., Roussel, F., and Ballet, J.J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:5886e089-5c28-46c1-9b0b-092dec35ad9a
uuid:5886e089-5c28-46c1-9b0b-092dec35ad9a
urnnbn:urn:nbn:cz:aba007-000dh6

Subject:

Cryptosporidium parvum, sinefungin, anti-cryptosporidial drug, rat model, and treatment

Type:

model:internalpart and TEXT

Format:

print

Description:

Cryptosporidium parvum causes life-threatening diarrhoea in immunocompromized, especially AIDS patients and the efficiency of proposed anti-cryptosporidial therapies is limited or doubtful. An immunosuppressed adult rat model of C. parvum infection was developed for screening molecules candidate for curative and preventive activity in human cryptosporidiosis. Among 31 drugs tested, lasalocid (2-10 mg/kg/24 h), and sinefungin (2-10 mg/kg/24 h), exhibited some activity against C. parvum infection. Oral sinefungin therapy resulted in a dose related suppression of oocysts shedding, which correlated with oocyst disappearance from ileum sections and was also efficient in preventing infection. Relapses were observed after discontinuation of curative sinefungin therapy, which suggests that the biliary tract, a major location and parasite reservoir which sustains persisting infection, was not cleared of parasites by the drug. Improved therapeutic procedures with sinefungin (or analogues) will result from current pharmacological studies.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

13-16 and 15-18

Source:

Folia parasitologica | 1994 Volume:41 | Number:1

Harvested from:

CDK

Metadata only:

false