Exercise can improve the cardiovascular health. However, the mechanism contributing to its beneficial effect on elderly patients with myocardial infarction is obscure. 20-month-old male Sprague-Dawley rats were used to establish myocardial infarction (MI) model by permanent ligation of the left anterior descending coronary artery (LAD) of the heart, followed by 4-week interval exercise training on a motor-driven rodent treadmill. The cardiac function, myocardial fibrosis, apoptosis, oxidative stress, and inflammatory responses were determined by using pressure transducer catheter, polygraph physiological data acquisition system, Masson's trichrome staining, and ELISA to evaluate the impact of post-MI exercise training on MI. Western blot were performed to detect the activation of AMPK/SIRT1/PGC-1α signaling in the hearts of aged rats. Exercise training significantly improved cardiac function and reduced the cardiac fibrosis. In infarcted heart, the apoptosis, oxidative stress, and inflammation were significantly reduced after 4-week exercise training. Mechanistically, AMPK/SIRT1/PGC-1α pathway was activated in the myocardial infarction area after exercise training, which might participate in the protection of cardiac function. Exercise training improves cardiac function in MI rats through reduction of apoptosis, oxidative stress, and inflammation, which may mediate by the activation of AMPK/SIRT1/PGC-1α signaling pathway.
The oldest historical resources and records about “hody” (traditional feast organized on the occasion of dedication of a church to a patron saint) from the 19th and 20th centuries mention existence of parades and the special position of boys and men in the whole “Hody” festival. “stárci” (selected senior boys) played the principal role in the life of the youth in the villages of Uherskohradišťsko. They were the driving force of all cultural and social events in the village, the main organizers of “Hody”. They were elected by “chasa” (all senior youth) for one year and they acquired certain rights and duties. the election of “stárci” was a great ceremony and a matter of prestige for the male youth. “stárci” had special attributes out of which “právo” (a wooden stick decorated with flowers, ribbons and spangles) was the most important one. Until the mid-20th century, girls did not take part in the “Hody” parade at all. It was performed solely by boys and married men. one evening was reserved for the married men. As part of the entertainment, they also had priority to a solo dance. In this way, “stárci” showed respect of the community of unmarried youth to married men who helped them to prepare “Hody”. The role of “stárci” has decreased within the last one hundred years, nonetheless it is still dominant. The boys are still conscious of the importance of this function.
The article tracks the journeys of selected American women artists of the second wave of feminist movement on their path through art institutions and their changing relation toward the figure of authority from the position of students to the one of art pedagogues. The text examines sexist conduct and language characteristic of and specific to the environment of art academies and the art world in general. Using the example of Feminist Art Program founded in 1970 by Judy Chicago at the Fresno University, it tries to assess power relations and teacher authority within the context of feminist art pedagogy. Furthermore, the text gives examples of problems encountered by Czech women artists regarding their access to authority. The article is based on a qualitative research and synthesis of interviews with American women artists who at some point of their careers taught studio art and tried to reconsider the authority they embodied., Zuzana Štefková., and Obsahuje bibliografii