Exercise improves cardiac function in the aged rats with myocardial infarction

Title:

Exercise improves cardiac function in the aged rats with myocardial infarction

Creator:

Chen, Yanping, Huang, Qiang, and Feng, Yuanxi

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:401a451d-b817-48ca-818e-3ff81680da08
uuid:401a451d-b817-48ca-818e-3ff81680da08
doi:10.33549/physiolres.934966

Subject:

myocardial infarction, exercise, apoptosis, oxidative stress, and inflammation

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Exercise can improve the cardiovascular health. However, the mechanism contributing to its beneficial effect on elderly patients with myocardial infarction is obscure. 20-month-old male Sprague-Dawley rats were used to establish myocardial infarction (MI) model by permanent ligation of the left anterior descending coronary artery (LAD) of the heart, followed by 4-week interval exercise training on a motor-driven rodent treadmill. The cardiac function, myocardial fibrosis, apoptosis, oxidative stress, and inflammatory responses were determined by using pressure transducer catheter, polygraph physiological data acquisition system, Masson's trichrome staining, and ELISA to evaluate the impact of post-MI exercise training on MI. Western blot were performed to detect the activation of AMPK/SIRT1/PGC-1α signaling in the hearts of aged rats. Exercise training significantly improved cardiac function and reduced the cardiac fibrosis. In infarcted heart, the apoptosis, oxidative stress, and inflammation were significantly reduced after 4-week exercise training. Mechanistically, AMPK/SIRT1/PGC-1α pathway was activated in the myocardial infarction area after exercise training, which might participate in the protection of cardiac function. Exercise training improves cardiac function in MI rats through reduction of apoptosis, oxidative stress, and inflammation, which may mediate by the activation of AMPK/SIRT1/PGC-1α signaling pathway.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

27-35

Source:

Physiological research | 2023 Volume:72 | Number:1

Harvested from:

CDK

Metadata only:

false