The effects of exercise on mechanical hyperalgesia, joint contracture, and muscle injury resulting from immobilization are not completely understood. This study aimed to investigate the effects of cyclic stretching on these parameters in a rat model of chronic post-cast pain (CPCP). Seventeen 8-week-old Wistar rats were randomly assigned to (1) control group, (2) immobilization (CPCP) group, or (3) immobilization and stretching exercise (CPCP+STR) group. In the CPCP and CPCP+STR groups, both hindlimbs of each rat were immobilized in full plantar flexion with a plaster cast for a 4-week period. In the CPCP+STR group, cyclic stretching exercise was performed 6 days/week for 2 weeks, beginning immediately after cast removal prior to reloading. Although mechanical hyperalgesia in the plantar skin and calf muscle, ankle joint contracture, and gastrocnemius muscle injury were observed in both immobilized groups, these changes were significantly less severe in the CPCP+STR group than in the CPCP group. These results clearly demonstrate the beneficial effect of cyclic stretching exercises on widespread mechanical hyperalgesia, joint contracture, and muscle injury in a rat model of CPCP., Kazuhiro Hayashi, Saori Fukuyasu-Matsuo, Takayuki Inoue, Mitsuhiro Fujiwara, Yuji Asai, Masahiro Iwata, Shigeyuki Suzuki., and Obsahuje bibliografii
A three-valued function $f\: V\rightarrow \{-1,0,1\}$ defined on the vertices of a graph $G=(V,E)$ is a minus total dominating function (MTDF) if the sum of its function values over any open neighborhood is at least one. That is, for every $v\in V$, $f(N(v))\ge 1$, where $N(v)$ consists of every vertex adjacent to $v$. The weight of an MTDF is $f(V)=\sum f(v)$, over all vertices $v\in V$. The minus total domination number of a graph $G$, denoted $\gamma _t^{-}(G)$, equals the minimum weight of an MTDF of $G$. In this paper, we discuss some properties of minus total domination on a graph $G$ and obtain a few lower bounds for $\gamma _t^{-}(G)$.