Search

Start Over Creator Štajn, A.

1. The activities of superoxide dismutase, catalase and ascorbic acid content in the liver of goldfish (carassius auratus gibelio bloch.) Exposed to cadmium

Creator:
Žikič, R. V., Štajn, A., Saičic, Z. S., Spasic, M. B., Ziemnicki, K., and Petrovic, V. M.
Type:
article, model:article, and TEXT
Subject:
cadmium, goldfish, superoxide dismutase, catalase, and ascorbic acid
Language:
English
Description:
The goldfish (Carassius auratus gibelio Bloch.) were exposed to cadmium in the concentration of 20 mg Cd/1 water under aquarium conditions for 1, 4, 7 and 15 days. After exposure to cadmium, the activities of superoxide dismutase (SOD) and catalase (CAT) were significantly decreased. At the same time, the liver ascorbic acid (AsA) content was increased.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. The effects of selenium on the antioxidant defense system in the liver of rats exposed to cadmium

Creator:
Ognjanović, B., Žikić, R. V., Štajn, A., Saičić, Z. S., Kostić, M. M., and Petrović, V. M.
Type:
article, model:article, and TEXT
Subject:
cadmium, selenium, rat, antioxidant defense system, and liver
Language:
English
Description:
Total superoxide dismutase (total SOD), copper zinc containing superoxide dismutase (CuZn SOD), and manganese superoxide dismutase (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione- S-transferase (GST) activities as well as ascorbic acid (AsA), and vitamin E (vit E) concentrations were analysed in the liver of rats exposed to cadmium (15 mg Cd/day/kg), selenium (7 fig Se/day/kg), and to cadmium + selenium (15 mg Cd + 7 ptg Se/day/kg), and in control animals. Cadmium caused a decrease of total SOD, Mn SOD, CAT and GSH-Px but an increase of GST activity in the liver of rats. Contrary to cadmium, selenium caused a significant increase of the activity of these enzymes except for GSH-Px. By concomitant exposure to both cadmium and selenium, the toxic effects of cadmium on the activity of mentioned enzymes we abolished. In all exposed groups, the activity of enzyme glutathione-S-transferase was enhanced, indicating its increased role in prevention of lipid peroxidation. Cadmium decreased the concentration of AsA and increased the concentration of vitamin E in the liver, while selenium increased the concentration of both vitamins. However, by concomitant administration of cadmium and selenium, these changes were diminished and tended to reach control values.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public