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Start Over Creator Devát, L.

1. Morphometric characteristics of cardiac hypertrophy induced by long-term inhibition of NO synthase

Creator:
Sládek, T., Gerová, M., Znojil, V., and Devát, L.
Type:
article, model:article, and TEXT
Subject:
NO deficiency, hypertension, morphometry, cardiac hypertrophy, myocyte, and capillary domain
Language:
English
Description:
Morphometry of cardiomyocytes and capillary domains in the left ventricle myocardium was performed in control rats and in rats treated with nitro-L-arginine methyl ester 50 mg/kg/day p.o. for a period of 8 weeks. The myocardial hypertrophy accompanying the NO-deficient hypertension induced by chronic inhibition of NO synthase is characterized by an increase in thickness of myocardial fibres and by relative rarefaction of the capillary bed, e.g. an alteration in myocardial structure which is typical for pressure overload hypertrophy.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Remodelling of septal branch of coronary artery and carotid artery in L-NAME treated rats

Creator:
Kristek, F., Gerová, M., Devát, L., and Varga, I.
Type:
article, model:article, and TEXT
Subject:
nitric oxide, coronary artery, carotid artery, and morphometry
Language:
English
Description:
Coronary and carotid artery structure was studied in rats in order to analyze the processes in the cardiovascular system in NO-deficient hypertension model. Long-term inhibition of NO synthase was induced by L-nitro arginine methyl ester (L-NAME, 50 mg/kg/day p.o.) for a period of 8 weeks. An increase in blood pressure and heart/body weight ratio confirmed the reliability of the model. The wall thickness as well as the calculated wall area of the coronary artery increased by 70 % and 50 %, respectively, in comparison to control vessels. The wall thickness and the calculated wall area of the carotid artery increased by 73 % and 70 %, respectively. Further analysis indicated that both the tunica intima and tunica media in the coronary and the carotid artery increased quantitatively in a similar manner. Remarkable differences were found in the contribution of cellular and noncellular components in the tunica media of the coronary and carotid arteries of experimental animals. The calculated extracellular area increased by 116 % in comparison to the control coronary artery and by 97 % in comparison to the control carotid artery. The increase in extracellular matrix of the tunica media of coronary and carotid arteries seems to be basic cause of the remodelling of the vessels studied.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public