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Start Over Creator Nováková, Zuzana

2. CT evaluated sarcopenia signals: shorter survival for small cell lung cancer patients

Creator:
Pekařová, Anna, Pekař, Matej, Daniš, Daniel, and Nováková, Zuzana
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
small cell lung cancer, survival, sarcopenia, psoas muscle density, and abdominal muscle area
Language:
English
Description:
Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from small cell lung cancer (SCLC), however, a universal indicator of sarcopenia usable in clinical practice is still missing. A novel indicator for describing the severity of cancer could be helpful in tailoring the anti-tumor therapy. The aim of this study was to evaluate the computed tomography (CT) scans of total muscle area and radiation attenuation in patients suffering from small cell lung cancer. We used staging CT scans performed at the time of diagnosis to measure total muscle area (TMA) and average psoas density (PD) at level of the 3rd lumbar vertebra. TMA and PD were statistically evaluated in association with overall survival and disease staging. We used Mann-Whitney test and Spearman´s correlation coefficient for statistical testing and p-value under 0.05 was considered statistically significant. Retrospectively we examined 47 patients suffering from SCLC (mean age 65.05±7.3 years, BMI 23.97±4.4 kg/m2 , BSA 1.77±0.2 m2 , 30-day mortality was 4.3 % with 10 months median survival). As sarcopenia was pointed TMA under 55 and 39 cm2 /m2 for men and women respectively. The sarcopenic patients had significantly shorter median survival (7 vs. 11 months, p=0.05). We observed a significant relationship between survival and performance status (Spearman´s correlation, R=-0.39, p=0.05). The patients were divided into two groups according to the extensive (ED, n=34) or limited (LD, n=13) form of the disease. We observed significant difference in PD (42.49±6.1 vs. 47.67±4.5 HU, p=0.006) between ED vs. LD groups.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Effects of peroral hormonal contraception on cardiovascular system: analysis of selected cardiovascular parameters in an adolescent cohort; a pilot project

Creator:
Pírek, Ondřej, Budinskaya, Ksenia, and Nováková, Zuzana
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
oral contraceptive pills, arterial stiffness, pulse wave velocity, and subendocardial viability index
Language:
English
Description:
Oral contraceptive pills (OCPs) have some strong advantages over more traditional types of contraception, including their consistently high contraceptive effect as well as multiple additional positive side effects. OCPs went through decades of intense pharmaceutical development and current formulas are well optimized – however, a handful of their negative side effects remain, including some that affect cardiovascular system, for example higher risk of hypertension, venous thromboembolism and increased arterial stiffness. The gold standard for arterial stiffness assessment is currently applanation tonometry, a method that relies on arterial pulse wave velocity measurement (PWV). Another possible method for arterial stiffness measurement is the use of the VaSera device, which measures cardio-ankle vascular index (CAVI). The aim of this study was to discover the effect of OCPs use on selected cardiovascular parameters related to arterial stiffness. We measured these cardiovascular parameters in the OCPs using group (OCP) and in the control group (CTRL) using applanation tonometer Sphygmocor and the VaSera device. Comparison of the data from both groups showed us significantly increased diastolic blood pressure (DBP) and carotid-radial pulse wave velocity (crPWV) as well as significantly lower subendocardial viability index (SVI) in the OCP. These results imply a negative effect of hormonal contraceptives on the cardiovascular system with most of the negative changes affecting the peripheral arteries. Despite this evidence supporting the hypothesis of OCPs having a negative effect on cardiovascular health, further research is necessary.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

5. Mineral water Vincentka and its influence on mucosal ulcers

Creator:
Budinskaya, Ksenia, Nádeníček, Jaroslav, Stračina, Tibor, Hendrych, Michal, Pírek, Ondřej, Bartáková, Anna, Šudáková, Magdaléna, Svízela, Vojtěch, Nováková, Zuzana, Nováková, Marie, and Babula, Petr
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
mineral water Vincentka, gastric ulcer, and oxidative stress
Language:
English
Description:
Gastropathy is one of the most common diseases of the human gastrointestinal tract. Apart from its consequences in the stomach, it is also manifested in other parts of the digestive tract, particularly in the duodenum. The aim of this pilot study was to verify on animal model the empirically observed alleviation of gastropathy symptoms in patients who underwent a drinking treatment of Vincentka natural mineral water during their spa treatment. Sixteen male Wistar rats were included in the study. The animals were randomly divided into two groups: experimental group (E; n=8) and control group (C; n=8). The experimental protocol consisted of three phases: (1) handling phase (7 days); (2) mineral water (E)/tap water (C) administration (7 days); (3) acute gastritis induction (1 day). Twenty-four hours after the induction of acute gastritis, the animals were sacrificed. The collected tissues (stomach and duodenum) and blood were examined by standard histological microscopy, and by immunohistochemical and biochemical methods. Histopathological analysis revealed significantly reduced damage to the gastric mucosa in the experimental group. Significantly different values of blood plasma antioxidant capacity, oxidative stress parameters and blood plasma biochemical parameters were also found. Based on these results, we conclude that the mineral water Vincentka has a positive impact on development and symptoms of acute gastric ulcers.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7. Variability of peripheral pulse wave velocity in patients with diabetes mellitus type 2 during orthostatic challenge

Creator:
Svačinová, Jana, Hrušková, Jana, Jakubík, Juraj, Budinskaya, Ksenia, Hidegová, Simona, Fabšík, Martin, Sieglová, Helena, Kaščáková, Zuzana, Novák, Jan, and Nováková, Zuzana
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
pulse wave velocity, variability, diabetes mellitus, arterial stiffness, and orthostasis
Language:
English
Description:
Diabetes mellitus 2 (DM2) is the seventh cause of death worldwide. One of the reasons is late diagnosis of vascular damage. Pulse wave velocity (PWV) has become an independent marker of arterial stiffness and cardiovascular risk. Moreover, the previous studies have shown the importance of beat-to-beat PWV measurement due to its variability among the heart cycle. However, variability of PWV (PWVv) of the whole body hasn't been examined yet. We have studied a group of DM II and heathy volunteers, to investigate the beat-to-beat mean PWV (PWVm) and PWVv in the different body positions. PWV of left lower and upper extremities were measured in DM2 (7 m/8 f, age 68±10 years, BP 158/90±19/9 mm Hg) and healthy controls (5 m/6 f, age 23±2 years, BP 117/76±9/5 mm Hg). Volunteers were lying in the resting position and of head-up-tilt in 45° (HUT) for 6 min. PWVv was evaluated as a mean power spectrum in the frequency bands LF and HF (0.04-0.15 Hz, 0.15-0.5 Hz). Resting PWVm of upper extremity was higher in DM2. HUT increased lower extremity PWVm only in DM2. Extremities PWVm ratio was significantly lower in DM2 during HUT compared to controls. LF and HF PWVv had the same response to HUT. Resting PWVv was higher in DM2. Lower extremity PWVv increased during HUT in both groups. PWVm and PWVv in DM2 differed between extremities and were significantly influenced by postural changes due to hydrostatic pressure. Increased resting PWVm and PWVv in DM2 is a marker of increased arterial stiffness.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public