Health Technology Assessment (HTA) denotes a process (resp. a study), the objective of which is to get an idea about clinical, economic and ethical aspects of a health technology, including its effect to the quality of life, and a consequent assessment. The output of this process is compiled under strict methodological conditions, and it has only a character of recommendation. Abroad, HTA is intensely used above all to complex comparing two (or several) technologies. When the origin of HTA goes back to 1960 ́s and 1970 ́s, the first information appeared in the Czech Republic in the beginning of this millennium. No Czech institution is a member of international organizations INEHTA and HTAi, which makes any access to foreign know- how more difficult. Although no complex study has been probably produced in the Czech Republic, some efforts to a larger utilization of HTA methods can be seen, above all in pharmacoeconomics. What discourages their higher utilization is a lack of interest in results of HTA studies from the side of health care providers, decision makers (the Ministry, regional administrations, health insurance companies), missing methodology, absence of methodological guidance (non-existence of a national agency), pending funding, and (non)-participation in international networks., Vladimír Rogalewicz, Ivana Juřičková, and Literatura