Acute orofacial pain is associated with significant disability and has a detrimental impact on quality of life. Although various origins of the pain in trigeminal territory can be identified an odontogenic pathology is the most common cause of acute orofacial pain in patients. Due to complex pathophysiology drugs with multitarget action might provide beneficial effect in pain management. The aim of the present study was to experimentally examine the anti-nociceptive effects of tapentadol, an opioid agonist and a norepinephrine reuptake inhibitor (MOR/NRI), in our animal model of orofacial pain. We tested the effect of tapentadol at gradual doses of 1, 2 and 5 mg/kg during thermal and mechanical stimulation in the trigeminal area of adult rats. We observed that tapentadol exhibits antinociceptive effect at dosages of 2 mg/kg and 5 mg/kg and only in association with mechanical stimulation.
Jsou rozebrány základní Purkyňovy objevy v této oblasti a její projekce do soudobých neurověd. Je zdůrazněn novátorský metodický a experimentální přístup Purkyněho při studiu zasahující do oblasti anatomie, fyziologie, farmakologie a dalších věd. V krátkosti jsou zmíněny i některé oblasti neurověd, které se v současné době velmi rozvíjejí, ale které Purkyně ve své době nemohl ovlivnit. and An analysis is made of Purkyně’s basic discoveries in this field and their projection in contemporary neuroscience. Purkyně’s innovative methodical and experimental approach, which influenced anatomy, physiology, pharmacology and other sciences, is also highlighted. Mention is also briefly made of some areas of neuroscience which are currently highly developed but which could not be studied in Purkyně’s time.