The present study was devised to assess the effects of cadmium chloride (CdCl2) administration on certain andrological, endocrinological and biochemical alterations in adult male rabbits (n=24). The animals were assigned to control (n=8) and experimental (n=16) group. Experimental group was orally administered with 1.5 mg/kg body weight of CdCl2. The trials were carried out for a total of 5 weeks and blood sampling was carried out on weekly basis. A gradual decrease was noticed for body weight in the experimental group from week 1 to 5, being significantly lower in week 4 and 5 (P<0.05). A similar decremented trend was noticed for serum testosterone level being significantly lower in experimental group in week 4 and 5 (P<0.001). Significantly lower values were noticed for prolactin in experimental group in week 4 and 5 (P<0.05), than in the control. On the contrary, serum cortisol level showed a gradual increase in experimental group, from week 1 to 5, being significantly higher in week 4 and 5 (P<0.05). Regarding the biochemical attributes, all the parameters under study revealed a gradually ascending trend. Statistical significance was, however, achieved in varying weeks and at varying levels. The total protein and albumin were significantly higher in week 4 and 5 (P<0.01); alanine aminotransferase in week 2 (P<0.01), 3 (P<0.001), 4 (P<0.01) and 5 (P<0.001); aspartate aminotransferase in week 1, 2, 3, 4 and 5 (P<0.01); and alkaline phosphatase in week 1, 2 (P<0.01), 3, 4 and 5 (P<0.0001), respectively. Overall mortality rate in experimental group was 68.75 (11/16). In a nutshell, Cd exposure results in adverse effects on all physiological parameters of body and may lead to lethal consequences., S. Sajjad, H. Malik, U. Farooq, F. Rashid, H. Nasim, S. Tariq, S. Rehman., and Obsahuje bibliografii
Current study evaluated the synergistic potential of propolis and
vitamin E against sub-acute toxicity of aluminum chloride on
different biochemical parameters and liver histology. Swiss albino
mice (n=42) were randomly divided into seven groups. Group I
received 0.2 ml of 0.9 % saline solution, Group II received
Propolis (50 mg/kg b.w.), Group III received vitamin E
(150 mg/kg b.w.), Group IV received AlCl3 50 mg/kg b.w.,
Group V received AlCl3 + Propolis, Group VI received AlCl3 +
vitamin E and Group VII received AlCl3 + propolis + vitamin E.
Blood and tissue samples were collected after 7 and 21 days. The
body weight of the animals significantly increased in all groups
except Group IV. The concentration of serum high density
lipoprotein significantly decreased in Group IV and increased in
Group V, VI and VII. The level of aspartate aminotransferase,
alanine transferase, alkaline phosphatase, triglycerides, total
cholesterol, and low density lipoprotein significantly increased in
AlCl3 treated group and increased in Group V, VI and VII. Tissue
sections were processed and stained by hematoxylin and eosin.
Group II showed cellular necrosis. Group V, VI showed decreased
number of vacuolization, sinusoidal spacing and macrophage cell
infiltration. Group VI showed less degenerative changes in the
third week. Vitamin E and propolis in combination with Al
provides more protection against AlCl3 induced toxicity.