The article deals with estimating deformation between the African and the Eurasian Plate in the Eastern Mediterranean on the basis of GPS coordinate time series. Two sources of velocities were used for processing. The first was the freely available site velocities from the European Permanent Network (EPN). The second was the Egyptian GPS permanent network velocities. Their values were determined by the following technique. Firstly, the Egyptian site coordinates were computed from GPS daily observations, using the fiducial EPN stations. The daily site coordinates at a given time interval result in coordinate time series, which were analysed and used on velocity estimation of the Egyptian stations. Then the apparatus of the mechanics of continuum was applied to all resultant velocities. The regions of possible mutual interactions between the Eurasian and the African Plate in the Eastern Mediterranean were detected. The basic idea of this contribution is the common processing of GPS daily measurements from the Egyptian permanent network together with the EPN data. The available Egyptian GPS data cover almost the last three years, which represents a sufficient time interval for velocity estimation. Introducing the Egyptian permanent GPS measurements into processing enables a better estimate of deformations in the Eastern Mediterranean., Antonín Zeman, Khalil Hassan, Jan Holešovský, Abdel Monem S. Mohamed, Zbyněk Novotný, Mahmoud M. Salah, Jan Kostelecký and Radwan M. Ali., and Obsahuje bibliografii