In the current work, a new notion of n-weak amenability of Banach algebras using homomorphisms, namely (ϕ, ψ)-n-weak amenability is introduced. Among many other things, some relations between (ϕ, ψ)-n-weak amenability of a Banach algebra A and Mm(A), the Banach algebra of m × m matrices with entries from A, are studied. Also, the relation of this new concept of amenability of a Banach algebra and its unitization is investigated. As an example, it is shown that the group algebra L 1 (G) is (ϕ, ψ)-n-weakly amenable for any bounded homomorphisms ϕ and ψ on L 1 (G).