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Start Over Creator Ujházy, Eduard

2. Impact of prenatal hypoxia on the development and behavior of the rat offspring

Creator:
Piešová, Michaela, Koprdová, Romana, Ujházy, Eduard, Kršková, Lucia, Olexová, Lucia, Morová, Martina, Senko, Tomáš, and Mach, Mojmír
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
gestational hypoxia, offspring, neurodevelopmental disturbances, and behavior rat
Language:
English
Description:
The healthy development of the fetus depends on the exact course of pregnancy and delivery. Therefore, prenatal hypoxia remains between the greatest threats to the developing fetus. Our study aimed to assess the impact of prenatal hypoxia on postnatal development and behavior of the rats, whose mothers were exposed to hypoxia (10.5 % O2) during a critical period of brain development on GD20 for 12 h. This prenatal insult resulted in a delay of sensorimotor development of hypoxic pups compared to the control group. Hypoxic pups also had lowered postnatal weight which in males persisted up to adulthood. In adulthood, hypoxic males showed anxiety-like behavior in the OF, higher sucrose preference, and lower levels of grimace scale (reflecting the degree of negative emotions) in the immobilization chamber compared to the control group. Moreover, hypoxic animals showed hyperactivity in EPM and LD tests, and hypoxic females had reduced sociability compared to the control group. In conclusion, our results indicate a possible relationship between prenatal hypoxia and changes in sociability, activity, and impaired emotion regulation in ADHD, ASD, or anxiety disorders. The fact that changes in observed parameters are manifested mostly in males confirms that male sex is more sensitive to prenatal insults.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. Rare causes of respiratory insufficiency in newborns

Creator:
Brucknerová, Jana, Babala, Jozef, Ujházy, Eduard, Mach, Mojmír, Juránek, Ivo, and Brucknerová, Ingrid
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
congenital lung masses, congenital pulmonary airway malformation, and newborn
Language:
English
Description:
Congenital lung masses (CLM) the rare group of causes of acute respiratory insufficiency (RI) in newborns include congenital airway pulmonary malformation (CAPM), congenital overinflation, bronchopulmonary sequestration, and bronchial atresia. The presenting group consists of 13 newborns who were admitted to the Neonatal Department of Intensive Medicine (NDIM) during January 1st 2015-December 31st 2019 (8 males, 5 females, 2 premature/11 term newborns, spontaneous delivery: 2, caesarean section: 11) with positive prenatal diagnosis of CAPM in all cases. In 2 cases prenatal intervention was performed (drainage of the amniotic fluid, attempt of thoracentesis). Signs of acute RI immediately after delivery were seen in 5 newborns. Postnatal echocardiographic investigation confirmed the presence of increased pulmonary pressure in 8 patients, no patient had congenital heart abnormality. A thorax x-ray was positive also in asymptomatic patients. Computed tomography in patients brought detailed information about the position, size and character of CAPM. Six patients underwent surgery. In 15.4 % right lungs were affected by cystic malformation and in 23 % left lungs were affected. A final diagnosis of CAPM was confirmed in 5 patients using histopathologic examination. Multidisciplinary cooperation during prenatal as well as postnatal period is necessary.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public