Data envelopment analysis (DEA) is a methodology for measuring best relative efficiencies of a group of peer decision-making units (DMUs) that take multiple inputs to produce multiple outputs. However, the traditional DEA model only aims to maximize the efficiency of the DMU under evaluation. This usually leads to very small weights (even zero weights) being assigned to some inputs or outputs. Correspondingly, these inputs or outputs have little or even no contribution to efficiency, which is unfair and irrational. The purpose of this paper is to address this problem. Two new weight-optimized models are proposed based upon the perspective of cross evaluation. Using the results of an Advanced Manufacturing Technology (AMT) example, it is found that all AMTs are fully sorted. The decision maker can easily choose the best AMT. In addition, unreasonable weights of AMTs are effectively avoided.
Vascular calcification (VC) is an independent risk factor for cardiovascular events and all-cause mortality with the absence of current treatment. This study aimed to investigate whether eIF2α phosphorylation inhibition could ameliorate VC. VC in rats was induced by administration of vitamin D3 (3×105 IU/kg, intramuscularly) plus nicotine (25 mg/kg, intragastrically). ISRIB (0.25 mg/kg·week), an inhibitor of eIF2α phosphorylation, ameliorated the elevation of calcium deposition and ALP activity in calcified rat aortas, accompanied by amelioration of increased SBP, PP, and PWV. The decreased protein levels of calponin and SM22α, and the increased levels of RUNX2 and BMP2 in calcified aorta were all rescued by ISRIB, while the increased levels of the GRP78, GRP94, and C/EBP homologous proteins in rats with VC were also attenuated. Moreover, ISRIB could prevent the elevation of eIF2α phosphorylation and ATF4, and partially inhibit PERK phosphorylation in the calcified aorta. These results suggested that an eIF2α phosphorylation inhibitor could ameliorate VC pathogenesis by blocking eIF2α/ATF4 signaling, which may provide a new target for VC prevention and treatment.