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143. A blood pact: the significance and implications of eIF4E on lymphocytic leukemia

Creator:
Venturi, V, Masek, T., and Martin Pospíšek
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
leukémie, leukemia, eukaryotic initiation factor 4E, eIF4E, lymphocytic leukemia, translation initiation, protein synthesis, hematological diseases, ALL, CLL, 14, and 612
Language:
English
Description:
Elevated levels of eukaryotic initiation factor 4E (eIF4E) are implicated in neoplasia, with cumulative evidence pointing to its role in the etiopathogenesis of hematological diseases. As a node of convergence for several oncogenic signaling pathways, eIF4E has attracted a great deal of interest from biologists and clinicians whose efforts have been targeting this translation factor and its biological circuits in the battle against leukemia. The role of eIF4E in myeloid leukemia has been ascertained and drugs targeting its functions have found their place in clinical trials. Little is known, however, about the pertinence of eIF4E to the biology of lymphocytic leukemia and a paucity of literature is available in this regard that prospectively evaluates the topic to guide practice in hematological cancer. A comprehensive analysis on the significance of eIF4E translation factor in the clinical picture of leukemia arises, therefore, as a compelling need. This review presents aspects of eIF4E involvement in the realm of the lymphoblastic leukemia status; translational control of immunological function via eIF4E and the state-of-the-art in drugs will also be outlined., V. Venturi, T. Masek, M. Pospisek., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

144. A Cauchy-Pompeiu formula in super Dunkl-Clifford analysis

Creator:
Yuan, Hongfen
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
matematika, mathematics, super Dunkl-Dirac operator, Stokes formula, Cauchy-Pompeiu integral formula, Morera's theorem, Painlevé theorem, 13, and 51
Language:
English
Description:
Using a distributional approach to integration in superspace, we investigate a Cauchy-Pompeiu integral formula in super Dunkl-Clifford analysis and several related results, such as Stokes formula, Morera's theorem and Painlevé theorem for super Dunkl-monogenic functions. These results are nice generalizations of well-known facts in complex analysis., Hongfen Yuan., and Obsahuje bibliografické odkazy
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

145. A characterization of a certain real hypersurface of type (A2) in a complex projective space

Creator:
Kim, Byung Hak, Kim, In-Bae, and Maeda, Sadahiro
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
matematika, mathematics, ruled real hypersurface, nonflat complex space form, real hypersurfaces of type (A2) in a complex projective space, geodesics, structure torsion, Hopf manifold, 13, and 51
Language:
English
Description:
In the class of real hypersurfaces M²n−¹ isometrically immersed into a nonflat complex space form Mn(c) of constant holomorphic sectional curvature c (≠ 0) which is either a complex projective space ℂPn(c) or a complex hyperbolic space ℂHn(c) according as c > 0 or c < 0, there are two typical examples. One is the class of all real hypersurfaces of type (A) and the other is the class of all ruled real hypersurfaces. Note that the former example are Hopf manifolds and the latter are non-Hopf manifolds. In this paper, inspired by a simple characterization of all ruled real hypersurfaces in Mn(c), we consider a certain real hypersurface of type (A2) in ℂPn(c) and give a geometric characterization of this Hopf manifold., Byung Hak Kim, In-Bae Kim, Sadahiro Maeda., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

146. A characterization of the Riemann extension in terms of harmonicity

Creator:
Bejan, Cornelia-Livia and Eken, Şemsi
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
matematika, mathematics, harmonické tenzorové pole, Semi-Riemannian manifold, cotangent bundle, natural Riemann extension, harmonic tensor field, 13, and 51
Language:
English
Description:
If (M,∇) is a manifold with a symmetric linear connection, then T*M can be endowed with the natural Riemann extension g¯ (O. Kowalski and M. Sekizawa (2011), M. Sekizawa (1987)). Here we continue to study the harmonicity with respect to g¯g¯ initiated by C. L.Bejan and O.Kowalski (2015). More precisely, we first construct a canonical almost para-complex structure PP on (T*M, g¯) and prove that P is harmonic (in the sense of E.Garciá-Río, L.Vanhecke and M. E.Vázquez-Abal (1997)) if and only if g¯ reduces to the classical Riemann extension introduced by E.M. Patterson and A.G. Walker (1952)., Cornelia-Livia Bejan, Şemsi Eken., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

147. A compactness result for polyharmonic maps in the critical dimension

Creator:
Zheng, Shenzhou
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
singularity (matematika), mathematics, singularities (mathematics), polyharmonic map, compactness, Coulomb moving frame, Palais-Smale sequence, removable singularity, 13, and 51
Language:
English
Description:
For n=2m\geqslant 4, let \Omega\in \mathbb{R}^{n} be a bounded smooth domain and N\subset \mathbb{R}^{L} a compact smooth Riemannian manifold without boundary. Suppose that \left \{ uk \right \}\in W^{m,2}\left ( \Omega ,N \right ) is a sequence of weak solutions in the critical dimension to the perturbed m-polyharmonic maps \frac{{\text{d}}}{{{\text{dt}}}}\left| {_{t = 0}{E_m}({\text{II}}(u + t\xi )) = 0} \right with Ωk → 0 in W^{m,2}\left( \Omega ,N \right )* and {u_k} \rightharpoonup u weakly in W^{m,2}\left( \Omega ,N \right ). Then u is an m-polyharmonic map. In particular, the space of m-polyharmonic maps is sequentially compact for the weak- W^{m,2} topology., Shenzhou Zheng., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

150. A comparative study of reactive hyperemia in human forearm skin and muscle

Creator:
Addor, G., Delachaux, A., Dischl, B., Hayoz, D., Liauder, L., Waeber, B., and Feihl, Francois
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, patologická fyziologie, ischemie, physiology, pathological physiology, ischemia, vasodilation, laser Doppler, strain gauge plethysmography, surrogate endpoint, acetylsalicylate, 14, and 612
Language:
English
Description:
Reactive hyperemia (RH) in forearm muscle or skin microcirculation has been considered as a surrogate endpoint in clinical studies of cardiovascular disea e. We evaluated two potential confounders that might limit such use of RH, namely laterality of measurement and intake of non-steroidal anti-inflammatory drugs (NSAIDS). Twenty-three young non-smoking healthy adults were enrolled. In Experiment 1 (n=16), the RH elicited by 3 min of ischemia was recorded in the muscle (strain gauge plethysmography, hand excluded) and skin (laser Doppler imaging) of both forearms. In Experiment 2 (n=7), RH was determined in the dominant forearm only, one hour following oral acetylsalicylic acid (1 g) or placebo. In Experiment 1, peak RH was identical in both forearms, and so were the corresponding durations of responses. RH lasted significantly less in muscle than in skin (p=0.003), a hitherto unrecognized fact. In the skin, acetylsalicylate reduced duration (43 vs. 57.4 s for placebo, p=0.03), without affecting the peak response. In muscle, duration tended to decrease with acetylsalicylate (21.4 vs. 26.0 s with placebo, p=0.06) and the peak increase in blood flow was blunted (27.2 vs. 32.4 ml/min/100 ml tissue with placebo, p=0.003). We conclude that, when using RH as a surrogate endpoint in studies of cardiovascular disease, a confounding by laterality of measurement need not be feared, but NSAIDS may have an influence, although perhaps not on the peak response in the skin., G. Addor, A. Delachaux, B. Dischl, D. Hayoz, L. Liaudet, B. Waeber, F. Feihl., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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