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872. Anthracycline therapy and 24-hour blood-pressure profile in long-term survivors of childhood cancer
- Creator:
- Zuzana Nováková, Jana Šťastná, Honzíková, K., Hana Hrstková, Nataša Honzíková, Eva Závodná, Bohumil Fišer, and Petr Honzík
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, krevní tlak, chronobiologie, blood pressure, chronobiology, anthracyclines, cardiotoxicity, childhood cancer, 14, and 612
- Language:
- English
- Description:
- In our previous studies, a decreased blood pressure was reported in children treated by anthracycline (AC). The aim of this study was to assess the long-term effects of AC anticancer therapy in 45 subjects aged 13-22 years by repeated 24-hour Holter monitoring of blood pressure. Sixty four aged-matched subjects served as controls. The differences between mean values of systolic (SBP) and diastolic blood pressure (DBP) in each hour of both groups were evaluated by Mann-Whitney test. Also the parameters of the least-squares fit of the sinusoidal curve in each subject were estimated (M - mesor, midline-estimating, a mean value of sinusoidal curve corresponds to 24-hours mean pressure; A - amplitude, double amplitude corresponds to nightday difference; Acr - acrophase is a time of maximal value of a sinusoidal curve). SBP and DBP was significantly lower only during night hours in anthracycline patients 19-22 years old. Also M was lower in this age subgroup of patients comparing to age matched controls (SBP: 112±6 mm Hg versus 117±7 mm Hg, p<0.05; DBP: 67±3 mm Hg versus 69±6 mm Hg, p<0.05), A was not different, Acr in patients was shifted one hour earlier (SBP: 2.4 p.m. versus 3.6 p.m., p<0.05; DBP: 2.1 p.m. versus 3.3 p.m., p<0.01). This corresponds to the shift of the morning blood-pressure increase seen on 24-hours blood pressure profiles. M correlated with age in controls (SBP: r=0.374, p<0.01; regression coefficient b=1.34 mm Hg/1 year; DBP: r=0.365, p<0.01; b=0.95 mm Hg/1 year), but not in patients (SBP: r=0.182, DBP: r=0.064). A and Acr were age-independent in all subjects. It is concluded that blood pressure in 19-22 years old AC patients is lower during night hours, the age-dependent increase of blood pressure seen in healthy controls between 13 and 22 years of age does not occur in patients. This finding is consistent with the long-lasting impairment of the sympathetic nervous system caused by anthracyclines., Z. Nováková ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
873. Anthropology of/in Post-Socialist World. 3rd International student conference of AntropoWeb. 2.-3. listopadu 2007, Plzeň
- Creator:
- Hyánková, Tereza
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Czech
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
874. Anti-Helicobacter pylori, anti-thyroid peroxidase, anti-thyroglobulin and anti-gastric parietal cells antibodies in Czech population
- Creator:
- Ivan Šterzl, Pavlína Hrdá, Petr Matucha, Jarmila Čeřovská, and Václav Zamrazil
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, endokrinologie, Helicobacter pylori, protilátky, endocrinology, antibodies, thyroid peroxidase, thyroglobulin, gastric parietal cells, 14, and 612
- Language:
- English
- Description:
- Autoimmune thyropathies are frequently linked to many infections, such as Helicobacter pylori, which are also supposed to play a role in their pathogenesis. The aim of this study was to evaluate the relationships between thyroid and gastric autoimmunity and H. pylori infection on a large sample of Czech population (n=1621) by monitoring the autoantibodies against thyroglobulin (anti-Tg) and thyroid peroxidase (anti-TPO) and gastric parietal cell (anti-GPC, representing thyrogastric syndrome) in correlation with antibodies against Helicobacter pylori (anti-H. pylori) of classes IgG and IgA. The interrelation between autoantibodies and H. pylori antibodies was assessed by H. pylori seropositivity. In H. pylori seropositive persons as compared to seronegative irrespective of age and sex, a higher occurrence of anti-TPO (10.4 % vs. 5.8 %, p=0.001) and anti-GPC (6.1 % vs. 1.7 %, p<0.001) was found. Differences in anti-TPO occurrence were significant in both men (7.0 % vs. 3.3 %, p=0.03) and women (12.7 % vs. 8.0 %, p=0.02), differences in anti-GPC occurrence were significant only in women (7.2 % vs. 1.7 %, p<0.001). Results of this study support the idea of a connection between infection of H. pylori and the occurrence of anti-TPO autoantibodies representing thyroid autoimmunity and gastric parietal cells autoantibodies representing the thyrogastric syndrome., I. Šterzl, P. Hrdá, P. Matucha, J. Čeřovská, V. Zamrazil., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
875. Anti-rómsky bilbord: analýza obrazu a médií
- Creator:
- Jana Plichtová and Paholíková, Vlasta
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Psychologie, psychologie, rasismus, stereotypy, racism, stereotypes, kritická systemická lingvistika, kritická diskurzívna analýza, anti-rómsky populizmus, dehonestácia, stigmatizácia, critical systemic linguistics, critical discursive analysis, anti-Roma populism, dehonestation, stigmatization, 17, and 159.9
- Language:
- Czech
- Description:
- Štúdia sa kriticky zaoberá diskurzívnymi aktivitami politikov a novinárov, ktorí slúžia ako modely pre imitáciu potvrdzovania, alebo naopak oponovania negatívnym stereotypom voči Rómom. Empiricky overuje tézu, že mediálny marketing politických strán zneužíva diskriminované a marginalizované skupiny na dosahovanie straníckych cieľov. Prostredníctvom kritickej systemickej lingvistiky analyzuje významové štruktúry predvolebného bilbordu, čím odhaľuje intencie komunikácie politickej strany s verejnosťou. Postupmi kritickej diskurzívnej analýzy mediálnych textov o anti-rómskom bilborde autorky identifikujú diskurzívne pozície rozmanitých aktérov, prípadne ich argumentačné stratégie, pričom kriticky reflektujú najmä asymetriu ich mediálnej prezentácie. Popisujú Diskuze / 401 sa spôsoby, akými parlamentná strana SNS implicitne (prostredníctvom bilbordu) a explicitne (vo svojich vyjadreniach) znevažuje celú etnickú skupinu. Z analýzy vyplýva, že hoci médiá uvádzajú názory rôznych diskurzívnych aktérov, v textoch chýba prezentácia argumentov, ktoré by pomohli širokej verejnosti pochopiť, prečo dehonestácia tejto stigmatizovanej skupiny je neprijateľná. Politické zneužívanie „rómskeho problému“ novinári demaskovali, avšak nevysvetlili negatívne dôsledky falošnej etnizácie nezamestnanosti, chudoby a verejnej dehonestácie Rómov., The study deals critically with discursive activities of politics and newspapermen which serve as models for imitation of confirmation or on the contrary of opposing the negative stereotypes against Roma. The thesis that the media marketing of political parties misuses the discriminated and marginalized groups for achieving the party goals is empirically verified. The meaning structures of pre-election billboard are analyzed by the means of critical systemic linguistics and thus reveals the intentions of communication of political party with the public. The authors identify the discursive positions of diverse participants, alternatively their argumentation strategies, and critically reflect especially the asymmetry of their media presentation by procedures of critical discursive analysis of media texts about the anti-Roma billboard. The ways how the parliament party SNS implicitly (through the billboard) and explicitly (in its statements) discredit the whole ethnic group are described. From the analysis follows that although media present the opinions of different discourse participants, the texts are lacking the presentation of arguments that could help the wide public to understand why the dehonestation of this stigmatized group is unacceptable. The political misuse of „Roma problem“ was unmasked by newspapermen but the negative consequences of false ethnic attribution of unemployment, poverty, and public dehonestation of Roma were not explained., Jana Plichtová, Vlasta Paholíková., and Obsahuje seznam literatury
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
876. Anti-suit injunctions in arbitral and judicial procedures in the Czech Republic
- Creator:
- Alexander J Bělohlávek
- Format:
- print, bez média, and svazek
- Type:
- model:article and TEXT
- Subject:
- Česko., ordre public, rozhodčí smlouvy, ústavní právo, jurisdikce, překážka věci pravomocně rozhodnuté, arbitration agreements, constitutional law, jurisdiction, res judicata, anti-suit injunctions, anti-arbitration injunctions, recognition and enforcement of judgements, recognition and enforcement of arbitral awards, arbitration, Charter of Fundamental Rights, Kompetenz-Kompezenz, Lis Pendens, procedural conditions, objective arbitrability, 16, and 34
- Language:
- English
- Description:
- Anti-suit injunctions are rather unknown in the civil law legal system of the Czech Repbulic. The policy reasons for the rejection of anti-suit injunctions in the Czech Republic are rooted in the constitutional right of every person to assert, through the legally prescribed procedure, their rights before an independent and impartial court or, in specified cases, before another body. In other words, every person may commence proceedings before a competent court, or respectively before any court or another body (e.g. like an arbitral tribunal, etc.), which is then exclusively empowered to rule on its jurisdiction. Therefore, there is also no distinction between anti-suit injunctions in domestic and international litigation. Czech law does not have any alternative procedural or substantive devices that may have similar functions as anti-suit injunctions related to arbitration. It means that it is not possible to obtain a court order against a respondent prohibiting the respondent from commencing or continuing court proceedings in another forum in violation of an arbitration agreement., Alexander J. Bělohlávek., and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
877. Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period
- Creator:
- Rezková, Markéta and Jan Kopecký
- Format:
- print, počítač, and online zdroj
- Type:
- model:article and TEXT
- Subject:
- cytokiny, cytokines, ixodid ticks, immunomodulation, 2, and 59
- Language:
- English
- Description:
- Tumour necrosis factor (TNF) plays a central role in the inflammatory process. In the skin, it contributes to immune containment of tick-transmitted pathogens like Borrelia burgdorferi. In the saliva of some tick species, active compounds are present that inhibit detection of TNF in specific ELISA. We compared the presence of anti-TNF activity in saliva or salivary gland extract from 11 tick species from the family Ixodidae and demonstrated it in genera Ixodes Latreille, 1795 and Haemaphysalis Koch, 1844. Analysis of anti-TNF activity in Ixodes ricinus (Linnaeus, 1758) saliva during the feeding period showed that it is present in the late, rapid phase of engorgement. Significance of anti-TNF activity for tick feeding and transmission of tick-borne pathogens is discussed., Markéta Rezková, Jan Kopecký., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
878. Antiatherogenic effect of simvastatin is not due to decrease of LDL cholesterol in ovariectomized golden Syrian hamster
- Creator:
- Pitha, J., Dagmar Bobková, Kovář, J., Havlíčková, J., and Rudolf Poledne
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, ateroskleróza, křečci, atherosclerosis, hamsters, ovariectomy, LDL particles, triglycerides, simvastatin, 14, and 612
- Language:
- English
- Description:
- The changes of the composition of blood lipoproteins caused by menopause could also change the effect of hypolipidemic therapy. Using an experimental model we studied the changes of serum lipids and the effect of immediate or delayed treatment with simvastatin on atherosclerosis after surgical menopause. Female golden Syrian hamster aged 6 months were fed hypercholesterolemic diet during the whole study. Atherosclerotic changes in thoracic and abdominal aortas were assessed by stereomicroscopic method after 12 weeks. Four experimental groups were studied: sham-operated animals (n=5), ovariectomized animals (n=9), ovariectomized animals treated for 12 weeks (n=10), and ovariectomized animals treated 4 weeks after ovariectomy for 8 weeks (n=9). The dose of simvastatin was 10 mg/kg of body weight. After 12 weeks, ovariectomized animals had tenfold higher concentration of triglycerides in LDL fraction and significantly higher prevalence of atherosclerosis than animals without ovariectomy. Treatment with simvastatin substantially decreased the prevalence of atherosclerotic changes, but otherwise did not change individual serum lipids including LDL cholesterol. However, it improved proportions of pro- and antiatherogenic serum lipids mainly by the increase of HDL cholesterol. The timing of simvastatin treatment had no significant effect on atherosclerotic changes or lipid parameters. Simvastatin treatment partly prevented atherosclerotic changes induced by ovariectomy. This effect was not mediated by decrease of LDL cholesterol, but by increase in HDL cholesterol., J. Pitha ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
879. Antibodies against b2-glycoprotein I (beta2-GP I) and Their Relationship to Fetoplacental Antigens
- Creator:
- Lenka Fialová, Malbohan, I., Ludmila Mikulíková, Olga Benešová, and Antonín Zwinger
- Format:
- print, bez média, and svazek
- Type:
- article, studie, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Anti-beta2-glycoprotein I, Antiphospholipid antibodies, alpha1-fetoprotein, Human chorionic gonadotrophin, Trophoblast-specific - beta1-glycoprotein, Pregnancy, 14, and 612
- Language:
- English
- Description:
- Binding of beta2-GP I to anionic phospholipids is thought to be the major antigen required in the reaction of anticardiolipin antibodies to phospholipids. The aim of this study was to investigate the changes of anti-beta2-GP I IgG during the first and second trimester of pregnancy and the relationship between the levels of anti-beta2-GP I and fetoplacental antigens and the correlation between anti-beta2-GP I IgG and antibodies against oxidized low-density lipoprotein IgG (oLAb) in serum of pregnant women. We determined anticardiolipin antibodies (ACA) IgG and maternal serum levels of alpha1-fetoprotein (AFP), human chorionic gonadotrophin (HCG) and trophoblast-specific beta1-glycoprotein (SP1) in 204 pregnant women in the first and second trimester. From this group we selected 52 serum samples positive for ACA IgG and 16 samples negative for ACA IgG. In the samples of selected patients, the levels of anti-b2-GP I IgG and oLAb IgG were determined. Anti-b2-GP I IgG levels significantly decreased in the second trimester (6.2±9.3 U/ml, mean ± S.D.) in comparison with the first trimester (8.3±10.4 U/ml) (p=0.05). Multiple of median (MoM) AFP correlated negatively but not significantly in the first trimester with anti-b2-GP I (r = -0.261, p = 0.12). In the second trimester this correlation was significantly negative (r = -0.278, p = 0.04). The Spearman correlation coefficients for MoM HCG and anti-beta2-GP I were 0.158 for the first trimester and 0.174 for the second trimester. MoM SP1 also did not correlate significantly with anti-beta2-GP I in both trimesters. The correlation between anti-beta2-GP I IgG and oLAb IgG was not significant (r = -0.06). In the first trimester 40 % serum samples were positive for anti-b2-GP I IgG and negative for oLAb IgG or vice versa, while 60 % samples in the second trimester were positive only for one determined autoantibody. We can conclude that the levels of a, L. Fialová, I. Malbohan, L. Mikulíková, O. Benešová, A. Zwinger., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
880. Antibodies against oxidized LDL - theory and clinical use
- Creator:
- Anna Steinerová, Racek, J., František Stožický, Tomáš Zima, Lenka Fialová, and Lapin, A.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, ateroskleróza, oxidační stres, atherosclerosis, oxidative stress, igoxLDL, low density lipoprotein, autoantibodies, 14, and 612
- Language:
- English
- Description:
- a1_Modification of low density lipoprotein (LDL) particles due to oxidation, glycation and binding of advanced glycation end-products (AGEs) or malondialdehyde (MDA, a final product of lipid peroxidation) is considered most important in the process of atherogenesis. Oxidatively modified LDL are distinguished by another receptor type, which was discovered on the surface of macrophages and was called the scavenger receptor. Uncontrolled intake of LDL converts macrophages to foam cells; their accumulation under the vascular endothelium is considered as the first stage of atherosclerosis. Oxidation of LDL is a complex process taking place in both the extra- and intracellular space. At the end of this oxidative process, modified LDL particles show chemotactic, cytotoxic and immunogenic properties. Oxidized LDL express a large number of epitopes and cause production of polyclonal autoantibodies against these products, especially against apoB100 modified by MDA and 4-hydroxynonenal. IgoxLDL (antibodies against oxidized LDL) can be demonstrated either directly in intimal lesions or as a component of circulating immune complexes. IgoxLDL do not form a homogeneous group but a varied mixture of antibodies-isoantibodies caused by HDL and LDL polymorphism, antibodies against the lipid phase of LDL and antibodies against modified apoB100 of the immunoglobulin class IgA or IgG. Antibodies against oxLDL were found in many diseases other than atherosclerosis such as diabetes mellitus, renovascular syndrome, uremia, rheumatic fever, morbus Bechtjerev or lupus erythematodes. Newborns have practically the same levels of IgoxLDL as their mothers; however, these values did not differ from those in the healthy population of non-pregnant women of the same age., a2_The decrease in IgoxLDL titer was very slow and lasted many months; that is why this parameter cannot be considered suitable for describing the rapid changes during oxidative stress of the organism. Positive correlation of IgoxLDL with antiphospholipids and other antibodies was repeatedly demonstrated; their determination can thus be used as a marker for the description of total production of autoantibodies in various diseases. The changes and correlations of IgoxLDL, anti-b-2-glycoprotein I IgG and antiphospholipid antibodies support the immunological link between thrombotic and atherosclerotic processes in the human body., A. Steinerová, J. Racek, F. Stožický, T. Zima, L. Fialová, A. Lapin., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public