In our previous studies, a decreased blood pressure was reported in children treated by anthracycline (AC). The aim of this study was to assess the long-term effects of AC anticancer therapy in 45 subjects aged 13-22 years by repeated 24-hour Holter monitoring of blood pressure. Sixty four aged-matched subjects served as controls. The differences between mean values of systolic (SBP) and diastolic blood pressure (DBP) in each hour of both groups were evaluated by Mann-Whitney test. Also the parameters of the least-squares fit of the sinusoidal curve in each subject were estimated (M - mesor, midline-estimating, a mean value of sinusoidal curve corresponds to 24-hours mean pressure; A - amplitude, double amplitude corresponds to nightday difference; Acr - acrophase is a time of maximal value of a sinusoidal curve). SBP and DBP was significantly lower only during night hours in anthracycline patients 19-22 years old. Also M was lower in this age subgroup of patients comparing to age matched controls (SBP: 112±6 mm Hg versus 117±7 mm Hg, p<0.05; DBP: 67±3 mm Hg versus 69±6 mm Hg, p<0.05), A was not different, Acr in patients was shifted one hour earlier (SBP: 2.4 p.m. versus 3.6 p.m., p<0.05; DBP: 2.1 p.m. versus 3.3 p.m., p<0.01). This corresponds to the shift of the morning blood-pressure increase seen on 24-hours blood pressure profiles. M correlated with age in controls (SBP: r=0.374, p<0.01; regression coefficient b=1.34 mm Hg/1 year; DBP: r=0.365, p<0.01; b=0.95 mm Hg/1 year), but not in patients (SBP: r=0.182, DBP: r=0.064). A and Acr were age-independent in all subjects. It is concluded that blood pressure in 19-22 years old AC patients is lower during night hours, the age-dependent increase of blood pressure seen in healthy controls between 13 and 22 years of age does not occur in patients. This finding is consistent with the long-lasting impairment of the sympathetic nervous system caused by anthracyclines., Z. Nováková ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
Posttraumatický stres a posttraumatický rozvoj osobnosti jsou v souvislosti s rakovinovým onemocněním dva často zmiňované fenomény. Cílem této studie je podat přehledný souhrn vybrané aktuální literatury k tématu a naznačit nově se otevírající pohled na možnost propojení obou jevů. Představujeme nejen integrativní přístup ke studované problematice, ale nastiňujeme i nová témata a směry dalšího výzkumu. Závěrem stručně informujeme o probíhajícím brněnském výzkumném projektu QOLOP, který se studiem obou jevů zabývá na populaci dětských onkologických pacientů a jejich rodin., Both the posttraumatic stress and the posttraumatic growth are often cited in relation to cancer. The aim of this paper is to give a review of current research in this field and briefly outline new perspective on possible connections between these concepts. The integrative approach has been presented in this review as well as new challenges and directions for future research. The basic information about ongoing QOLOP study on posttraumatic stress and growth in pediatric oncology patients and their families is provided in a nutshell at the end., Alena Slezáčková, Martin Loučka, Kateřina Bartošová., and Obsahuje seznam literatury