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512. Efekt tyroxínu na morfologické zmeny n. medianus u pacientov s novodiagnostikovanou primárnou hypotyreózou
- Creator:
- Holováčová, D., Kužma, Martin, Killinger, Zdenko, and Payer, Juraj
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, abstrakt z konference, and TEXT
- Language:
- Czech and Slovak
- Description:
- D. Holováčová, M. Kužma, Z. Killinger, J. Payer
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
513. Efektivita diagnostiky gastrinómov v súbore Národného centra pre rezistentné peptické vredy a endokrinne aktívne nádory gastrointestinálneho traktu
- Creator:
- Hyrdel, P., Schnierer, M., Lipták, Peter, and Hyrdel, Rudolf
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, abstrakt z konference, and TEXT
- Language:
- Czech and Slovak
- Description:
- P. Hyrdel, M. Schnierer, P. Lipták, R. Hyrdel
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
514. Efektivita dočasné imobilizace po operaci syndromu karpálního tunelu
- Creator:
- Fibír, Aleš, Čáp, Robert, and Vaněk, Jiří
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, srovnávací studie, and TEXT
- Subject:
- lidé, lidé středního věku, mužské pohlaví, ženské pohlaví, prospektivní studie, syndrom karpálního tunelu--chirurgie--terapie, pooperační péče--metody, fyzické omezení, dlahy, výsledek terapie, statistika jako téma, elektromyografie--statistika a číselné údaje, nervus medianus--fyziologie, spokojenost pacientů--statistika a číselné údaje, síla ruky--fyziologie, dekomprese chirurgická, otevřená dekomprese, dlahování, and distální motorická latence
- Language:
- Czech and English
- Description:
- Cíl: Správný pooperační režim je důležitou součástí rekonvalescence po dekompresi karpálního tunelu. Cílem této prospektivní randomizované studie je zjistit, zda pooperační dočasné dlahování má klinicky významný efekt, nebo zda není naopak zbytečné. Výsledky dosud publikovaných prací nedávají jasné, prokazatelné a jednoznačné doporučení. Soubor a metodika: Do souboru bylo zařazeno celkem 72 pacientů s klinicky a elektromyograficky prokázaným syndromem karpálního tunelu, kteří byli randomizováni do dvou skupin. V první skupině byla pacientům po operaci na dva týdny přiložena dorzální dlaha fixující zápěstí v neutrální poloze a v druhé skupině dlaha použita nebyla. Před operací i po operaci byla hodnocena distální motorická latence, síla stisku a míra subjektivních obtíží pomocí specializovaných dotazníků DASH (Disabilities of Arm, Shoulder and Hand Questionnaire) a Bostonského dotazníku (Boston Carpal Tunnel Questionnaire). Výsledky: Po operaci došlo ke zkrácení distální motorické latence a mírnému snížení síly stisku, ale mezi skupinami nebyly nalezeny statisticky významné rozdíly (p > 0,05). Po operaci došlo také k předpokládanému zmírnění subjektivních obtíží, objektivizovanému dotazníkovými koeficienty, ale mezi skupinami nebyl nalezen statisticky významný rozdíl (p > 0,05). Závěr: Podle našich zjištění dočasné dlahování po otevřené dekompresi karpálního tunelu ve srovnání s nedlahovanou skupinou nezlepšuje výsledky chirurgické léčby. Používání dlahy v této indikaci se jeví jako nadbytečné jak z lékařského, tak z ekonomického pohledu. Na druhou stranu dočasné dlahování po operaci výsledky operační léčby nezhoršuje., Aim: Correct post-operative care is an important part of recovery after carpal tunnel decompression. The aim of this prospective randomized study was to determine whether postoperative temporary splinting has a clinically significant effect, or whether it is unnecessary. The results of published data do not give clear, demonstrable and unambiguous recommendations. Material and methods: A total of 72 patients with clinically and electrodiagnostically established diagnosis of carpal tunnel syndrome were randomized into two groups. The first group included patients with a dorsal splint, fixing the wrist in a neutral position for two weeks after surgery, whereas the second group included patients, in whom the splint was not used after surgery. Distal motor latency, grip strength and degree of subjective symptoms were assessed before and after surgery using specific questionnaires, namely the DASH questionnaire (Disabilities of Arm, Shoulder and Hand) and the Boston questionnaire (Boston Carpal Tunnel Questionnaire). Results: After surgery, there was a reduction of distal motor latency and a moderate reduction of grip strength, but there were no statistically significant differences (p > 0.05) between the two groups. After surgery, the anticipated improvement of subjective symptoms was achieved, objectified by questionnaire coefficients. However, there was no statistically significant difference (p > 0.05) between the two groups either. Conclusion: According to our findings, temporary splinting after open carpal tunnel decompression does not improve the results of surgical treatment compared to the non-splinted group. Using the splint in this indication seems to be redundant from the medical and economic point of view. On the other hand, temporary splinting after surgery does not cause worsening of the results of surgical treatment. Key words: carpal tunnel syndrome – surgical decompression – immobilisation – splints – postoperative care – electromyography The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers., and A. Fibír, R. Čáp, J. Vaněk
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
515. Effect of collagen I gel on apoptosis of rat hepatic stellate cells
- Creator:
- Bittnerová, Lenka, Jiroutová, Alena, Rudolf, Emil, Řezáčová, Martina, and Kanta, Jiří
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT
- Subject:
- zvířata, apoptóza--účinky léků, chlorid uhličitý, buněčné kultury, kolagen typu I--farmakologie, cykloheximid, cytochalasin D, modely nemocí na zvířatech, gliotoxin, jaterní hvězdicovité buňky--účinky léků--patologie, jaterní cirhóza--patologie, mužské pohlaví, krysy, and potkani Sprague-Dawley
- Language:
- English
- Description:
- Activated hepatic stellate cells (HSC) are a major source offibrous proteins in cirrhotic liver. Inducing or accelerating their apoptosis is a potential way of liver fibrosis treatment. Extracellular matrix (ECM) surrounding cells in tissue affects their differentiation, migration, proliferation and function. Type I collagen is the main ECM component in fibrotic liver. We have examined how this protein modifies apoptosis of normal rat HSC induced by gliotoxin, cycloheximide and cytochalasin D in vitro and spontaneous apoptosis of HSC isolated from CCl4-damaged liver. We have found that type I collagen gel enhances HSC apoptosis regardless of the agent triggering this process. and L. Bittnerová, A. Jiroutová, E. Rudolf, M. Rezácová, J. Kanta
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
516. Effects of rehabilitation services on anxiety, depression, care-giving burden and perceived social support of stroke caregivers
- Creator:
- Karahan, Ali Yavuz, Kucuksen, Sami, Yilmaz, Halim, Salli, Ali, Gungor, Tayfun, and Sahin, Muhammed
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, klinické zkoušky, časopisecké články, and TEXT
- Subject:
- adaptace psychologická, úzkost--epidemiologie, osoby pečující o pacienty--psychologie, deprese--epidemiologie, posuzování pracovní neschopnosti, ženské pohlaví, lidé, mužské pohlaví, lidé středního věku, prospektivní studie, psychiatrické posuzovací škály, sociální opora, cévní mozková příhoda--ošetřování--rehabilitace, and epidemiologie
- Language:
- English
- Description:
- Background: Few data are available on the specific care giving-related problems of stroke patient’s caregivers and factors that influence the burden of these caregivers. Aim: To study the influences of the active rehabilitation process on anxiety, depression, care burden and perceived social support level of stroke patients caregivers. Design: A prospective clinical trial. Setting: Patients and caregivers entering a rehabilitation program at a university hospital in Turkey. Populations: Ninety patients with a first episode of stroke and 90 caregivers responsible for their care were recruited for our study. Methods: Patients and caregivers were assessed before and after the active rehabilitation process. The functional disability level of the patients was assessed by Functional Independence Measure (FIM). The Beck Anxiety Scale (BAS) and the Beck Depression Scale (BDS) were used for anxiety and depression assessment, the Zarit Care Burden Scale (ZCBS) for care burden assessment and the Multi-Dimensional Scale of Perceived Social Support (MDSPSS) for perceived social support assessment. Results: A statistically significant rise is observed in the special person sub-assessment of MDSPSS in both female and male caregivers. Also, a significant decrease in care burden, anxiety and depression levels of caregivers was noted after the rehabilitation program (p < 0.05). Conclusion: Caregivers accept the rehabilitation period as important social support in addition to the support provided by family and friends. Also, our positive results were associated with an improvement in the patients’ functional level and an increase in the acquisition of knowledge and skill required of caregivers in order to provide care during rehabilitation. Clinical Rehabilitation Impact: The rehabilitation team should be aware of the fact that the perceived care burden may be greater due to the lack of knowledge concerning available resources and due to the inability to cope with stress effectively. and A. Y. Karahan, S. Kucuksen, H. Yilmaz, A. Salli, T. Gungor, M. Sahin
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
517. Efficacy of low-dose tocilizumab on relapsing adult-onset still's disease
- Creator:
- Vandemergel, Xavier and Vandergheynst, Frédéric
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, časopisecké články, and TEXT
- Subject:
- dospělí, antiflogistika--terapeutické užití, monoklonální protilátky humanizované--aplikace a dávkování--terapeutické užití, antirevmatika--aplikace a dávkování--terapeutické užití, vztah mezi dávkou a účinkem léčiva, kombinovaná farmakoterapie, ženské pohlaví, glukokortikoidy--terapeutické užití, lidé, methylprednisolon--terapeutické užití, recidiva, Stillova nemoc - počátek v dospělosti--farmakoterapie, and výsledek terapie
- Language:
- English
- Description:
- Still's disease is an inflammatory disorder of unknown etiology. First-line therapy is based on corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) but the frequency of relapses and corticosteroid-induced adverse events are limiting factors. The efficacy of intravenous tocilizumab (TCZ) has been shown at a dose of 8 mg/kg but the corticosteroid-sparing effect of intravenous low-dose TCZ followed by subcutaneous (SC) injection in the course of the disease has been poorly investigated. We report the case of a 28-year old Caucasian woman presenting a relapse of Still's disease eleven months after diagnosis under treatment with 6 mg of methylprednisolone. TCZ at a dose of 4 mg/kg every 2 weeks was combined with 32 mg of methylprednisolone, followed by 162 mg SC every 3 weeks. Evolution was rapidly favourable with a decrease in corticosteroid doses. We reviewed previously published cases. and X. Vandemergel, F. Vandergheynst
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
518. Efficacy of topiramate as add-on therapy in two different types of progressive myoclonic epilepsy
- Creator:
- Demir, Caner Feyzi, Ozdemir, Hasan Hüseyin, and Müngen, Bülent
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, časopisecké články, and TEXT
- Subject:
- antikonvulzíva--terapeutické užití, kombinovaná farmakoterapie, ženské pohlaví, fruktosa--analogy a deriváty--terapeutické užití, lidé, myoklonické epilepsie progresivní--farmakoterapie, and mladý dospělý
- Language:
- English
- Description:
- The present article describes two unrelated cases of progressive myoclonic epilepsy (PME) of the Lafora's disease and Unverricht-Lundborg types who were treated with topiramate (TPM) as add-on therapy for their myoclonus. After the initiation of topiramate therapy both cases responded with marked decrease in myoclonic seizure frequency and improvement of quality of life. Topiramate appears to be a useful alternative agent in cases of PME and could be consider for adjunctive therapy. and CF. Demir, HH. Ozdemir, B. Müngen
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
519. eGFR a problémy interpretace rovnic CKD-EPI
- Creator:
- Jabor, Antonín, Franeková, J., Kubíček, Zdeněk, and Šálek, Tomáš
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, and TEXT
- Subject:
- diabetes mellitus--patofyziologie, chronické selhání ledvin--diagnóza--epidemiologie--klasifikace, vyšetření funkce ledvin, glomerulární filtrace - hodnota, kreatinin--analýza, cystatin C--analýza, klinické laboratorní techniky--metody--přístrojové vybavení, interpretace statistických dat, numerická analýza pomocí počítače, průřezové studie, retrospektivní studie, věkové faktory, ženské pohlaví, mužské pohlaví, and lidé
- Language:
- Czech and English
- Description:
- Jabor A., Franeková J., Kubíček Z., Šálek T. and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
520. Egg allergy in adolescent and adult patient suffering from atopic dermatitis-association with concomitant allergic diseases
- Creator:
- Čelakovská, Jarmila, Ettlerová, Květuše, Ettler, Karel, and Bukač, Josef
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, časopisecké články, and TEXT
- Subject:
- dospělí, atopická dermatitida--komplikace--imunologie, alergie na vejce--komplikace--imunologie, ženské pohlaví, lidé, alergie--komplikace, and mužské pohlaví
- Language:
- English
- Description:
- BACKGROUND: A few reports demonstrate the occurrence of egg allergy in adolescent and adult patients suffering from atopic dermatitis and the association of this allergy to other food and aeroallergens. AIMS AND OBJECTIVES: The aim of this study is to evaluate the occurrence of egg allergy in patients suffering from atopic dermatitis at the age 14 years and older and to evaluate the relationship between egg allergy or egg sensitisation and the sensitisation to dust, mites, feather, and animal dander. MATERIALS AND METHODS: Complete dermatological and allergological examination was performed. These parameters were examined: food allergy and food sensitisation to egg white and yolk, to mites, animal dander (mixture), feather and dust. The statistical evaluation of the relations among egg allergy, egg sensitisation and sensitisation to mites, animal dander (mixture), feather and dust was performed. Two hundred and eighty eight patients were included in the study (90 men, 198 women, with the average age 25.2). RESULTS AND CONCLUSION: Egg allergy was recorded in 5% and egg sensitisation in 20% of patients; sensitisation to dust is recorded more often in patients with positive results in sIgE for egg white and/or yolk. and J. Čelakovská, K. Ettlerová, K. Ettler, J. Bukač
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public