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662. The relationship between concentration of triacylglycerols and free radicals caused by fatty acid composition of triacylglycerols in diabetic patients
- Creator:
- Vecka, Marek, Tvrzická, Eva, and Votruba, Miloš
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, práce podpořená grantem, and TEXT
- Subject:
- diabetes mellitus 2. typu, volné radikály--chemie, kyseliny mastné--analýza, peroxidace lipidů, triglyceridy, plynová chromatografie s hmotnostně spektrometrickou detekcí, lidé, lidé středního věku, mužské pohlaví, and ženské pohlaví
- Language:
- Czech and English
- Description:
- Cíl práce: Lipoperoxidace je dávána do příčinné souvislosti s rozvojem nejdůležitějších rizikových faktorů kardiovaskulárních onemocnění. Lipoperoxidační procesy jsou důsledkem reakcí lipidů s volnými radikály bez ohledu na jejich původ. Vztah mezi triacylglyceroly (TAG) a volnými radikály (VR) není zcela jasný. Může se dokonce stát, že hypertriacylglycerolémie je doprovázena nízkými koncentracemi VR a naopak. Jedno z možných vysvětlení spočívá ve vztahu lipoperoxidace a složení mastných kyselin v molekulách TAG. Cílem této studie bylo analyzovat vztah složení mastných kyselin v TAG a produkci VR u pacientů trpících diabetes mellitus 2. typu. Typ studie: observační s kontrolní skupinou Materiál a metody: Studie zahrnovala 18 normotriacylglycerolemických (NTG) jedinců (M/F 12/6) a 24 hypertriacylglycerolemických (HTG) jedinců (M/F 16/8). Pacienti v obou skupinách byli diabetici 2. typu. Analýzu mastných kyselin v triacylglycerolech plazmy jsme provedli kapilární plynovou chromatografií a koncentrace volných radikálů byly změřeny přímou spektrofotometrií. Statistické analýzy (parametrické i neparametrické) byly provedeny pomocí statistického software STATISTICA pro Windows. Výsledky: Ve skupině HTG jsme pozorovali nižší zastoupení kyseliny myristové (14:0) (1.62 [1.23-2.07] vs. 1.90 [1.72-2.79], p = 0.022, [medián (1.-3. kvartil]) a vyšší poměr alfa-linolenové kyseliny (18:3n-3) (1.51 [1.21-1.86] vs 1.16 [1.02-1.42], p = 0.021). Poměr kyselin arachidonové/eikosapentaenové byl ve skupině HTG nižší (5.54 [3.62-7.98] vs 7.25 [5.98-15.12], p = 0.027). Když jsme HTG skupinu dále rozdělili podle koncentrací VR na tercily, prokázali jsme nižší hodnoty poměru kyseliny arachidonová/eikosapentaenová ve druhém tercilu (4.05 [2.66-4.67] vs 7.64 [5.83-11.00], 1. tercil, a 6.21 [3.20-8.31], 3. tercil p = 0.019). V spojených HTG+NTG skupinách jsme zaznamenali negativní korelaci mezi MA a TAG (r = -0.3153, p = 0.045). V triaclylglycerolech jsme prokázali pozitivní korelace VR a kyseliny stearové (p < 0.001) spolu s negativní korelací některých n-6 vícenenasycených mastných kyselin (18:3n-6, p < 0.05, 22:5n-6, p < 0.01). Závěr: Zastoupení mastných kyselin v molekulách TAG je spojeno s tvorbou VR. Nicméně do tohoto vztahu vstupují i jiné faktory., Objective: The lipoperoxidation plays a causal role in the development of most important risk factors of cardiovascular disease. The lipoperoxidation results from the reaction of lipid molecules with free radicals, regardless of their origin. The relationship between triacylglycerols (TAG) and the free radicals (FR) amount is not clear. Thus, it can turn up that the hypertriacylglyceridaemia is accompanied with the low values of FR, or vice versa. One possible explanation of this phenomenon is that the degree of lipoperoxidation of TAG is dependent on the composition of fatty acids (FA) in their molecule. Therefore, the aim of this study was to analyze FA composition in TAG and its relationship to FR production in type 2 diabetes mellitus. Design: observational study with internal control group Material and Methods: 18 normotriacylglycerolemic (NTG) individuals (12M/6F) and 24 hypertriacylglycerolemic (HTG) patients (16M/8F). Patients in both groups were persons, suffering from type 2 diabetes mellitus. Fatty acid analysis of plasma triacylglycerols was performed by gas chromatography and free radicals were determined by direct spectrophotometric method. Statistical analyses (both parametric and non-parametric) were performed with the statistical software STATISTICA for Windows. Results: We found lower content of myristic acid (14:0) (1.62 [1.23-2.07] vs. 1.90 [1.72-2.79], p = 0.022, [median (1st-3rd quartile)]) and higher content of alpha-linolenic acid (18:3n-3) (1.51 [1.21-1.86] vs. 1.16 [1.02-1.42], p = 0.021) in HTG group. The ratio of arachidonic/eicosapentaenoic acid was in HTG group lower (5.54 [3.62-7.98] vs. 7.25 [5.98-15.12], p = 0.027). When the HTG group was stratified into the tertiles by the FR concentrations, we observed lower values in the second tertile for ratios based on arachidonic acid (20:4n-6) and eicosapentaenoic acid (20:5n-3) (4.05 [2.66-4.67] vs. 7.64 [5.83-11.00], 1st tertile, and 6.21 [3.20-8.31], 3rd tertile, p = 0.019). In pooled groups, we proved negative correlation between MA and TAG (r = -0.3153, p = 0.045) and the link between FR and FA composition of TAG expressed as positive relationship of FR with content of stearic acid (p < 0.001) and negative correlation with some n-6 polyunsaturated fatty acids (18:3n-6, p < 0.05, 22:5n-6, p < 0.01). Conclusion: The composition of FA in TAG molecules has undoubtedly some relationship to the FR generation. However, the other factors seem to play a role, since the relationship is not straightforward within entire FR range., and Vecka M., Tvrzická E., Votruba M.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
663. The Tale of the Landscape in the Czech Lands in the 19th Century /
- Creator:
- Vyskočil, Aleš,
- Type:
- text and studie
- Subject:
- Historická geografie, krajina kulturní, krajina historická, české země 1792-1918, and vědy o neživé přírodě, přírodní prostředí, astronomie
- Language:
- English
- Description:
- Příběh krajiny 19. století v českých zemích.
- Rights:
- unknown
664. The TT genotype of the MTHFR 677C > T polymorphism increases susceptibility to premature coronary artery disease in interaction with some of the traditional risk factors
- Creator:
- Sarecka-Hujar, Beata, Zak, Iwona, and Krauze, Jolanta
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT
- Subject:
- dospělí, nemoci koronárních tepen--genetika, ženské pohlaví, genetická predispozice k nemoci, genotyp, lidé, lipidy--krev, mužské pohlaví, methylentetrahydrofolátreduktasa (NADPH2)--genetika, polymorfismus genetický, rizikové faktory, and kouření
- Language:
- English
- Description:
- BACKGROUND: The presence of several risk factors (genetic and non-genetic) has greater impact on the risk of premature coronary artery disease (CAD) than single risk factor. OBJECTIVE: The aim of the study was to establish possible relations between genotypes and alleles of 677C>T polymorphism of MTHFR gene and some traditional risk factors e.g. elevated levels of lipid parameters and smoking in development of premature CAD. METHODS: The groups comprised 152 patients with angiographically documented premature CAD (aged 42.9 +/- 5.5) and 121 age-matched blood donors (aged 42.3 +/- 6.5) were studied. The MTHFR 677C>T polymorphism was genotyped with Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. RESULTS: Patients with TT genotype who simultaneously smoked had increased risk of premature CAD compared to non-smoking cases with CC genotype (OR = 24.62). We also found that individuals with TT genotype and elevated LDL-cholesterol (LDL-chol.) level had significantly higher risk of CAD (OR = 9.92) than individuals with normal LDL-chol. level and CC genotype. CONCLUSIONS: The present study shows that simultaneous presence of MTHFR TT genotype and smoking or elevated levels of LDL-chol. influences the risk of premature CAD. This findings give interesting contribution to gene-environment interaction problem that may have clinical implications in the future. and B. Sarecka-Hujar, I. Zak, J. Krauze
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
665. Therapeutic erythrocytapheresis in the initial treatment of hereditary hemochromatosis
- Creator:
- Řeháček, Vít, Bláha, Milan, Jiroušová, Hana, Černohorská, Jitka, and Papoušek, Petr
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, časopisecké články, and TEXT
- Subject:
- dospělí, staří, krevní složky - separace, transfuze erytrocytů, erytrocyty - objem, ženské pohlaví, hematokrit, hemochromatóza--krev--genetika--terapie, lidé, železo--krev, mužské pohlaví, lidé středního věku, and transferin--analýza
- Language:
- English
- Description:
- BACKGROUND: The current treatment of hereditary hemochromatosis (HH) consists of performing periodic whole blood phlebotomies. Erythrocytapheresis (EA) can remove up to three times more red blood cells per single procedure and could thus have a clinical benefit. A prospective study of 30 consecutive cases of HH were included in a periodic EA program. METHODS AND PATIENTS: EA were performed using a discontinuous flow cell separators. The protocol consisted of a bimonthly EA until normalization of the serum ferritin was reached. The aim was to reduce the total erythrocyte volume by 25-35%, eventually, to adjust the amount so that hematocrit would not drop below 0.25. RESULTS: 530 +/- 101 ml of erythrocytes were removed (median 517, range 116-761 ml). Iron depletion (ferritin < 20 microg/l) was achieved in all patients after a mean 6.9 +/- 7.6 months, median 5 months, range 1-36 months and a mean 14 EA sessions. The procedures were well tolerated and there were no severe side-effects. CONCLUSIONS: We conclude that HH patients treated with EA achieved iron depletion quickly under good conditions of tolerance. The efficacy, speed, tolerability, and more favorable schedule of an EA program facilitate treatment of HH. and V. Rehácek, M. Bláha, H. Jirousová, J. Cernohorská, P. Papousek
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
666. Three Encounters with Karl W. Deutsch /
- Creator:
- Hroch, Miroslav,
- Subject:
- Deutsch, Karl Wolfgang,, politologové američtí, národ, nacionalismus, komunikace sociální, světové dějiny od r. 1945 do současnosti, USA, národnosti, vztahy mezi národnostmi a národní hnutí, and právní vědy, politologie, právníci, politologové
- Language:
- English
- Rights:
- unknown
667. Transcutaneous Serdev suture for buttock’s lift
- Creator:
- Serdev, Nikolay P.
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- minimálně invazivní chirurgické výkony--metody, chirurgie plastická, představa o vlastním těle, sutura--využití, hýždě--chirurgie, šicí techniky, postup, kožní aplikace, tuková tkáň--chirurgie, lipektomie--metody, ženské pohlaví, lidé, and technika Serdev
- Language:
- English
- Description:
- This article presents the author's technique and experience in the treatment of the flaccid "unhappy buttock" form with his surgical procedure of buttock lift by suture, without incision scars. The author first presented this new operation technique on a national level at the 2nd Annual Meeting of the National Bulgarian Society for Aesthetic Surgery and Aesthetic Medicine in Sofia on March 18, 1994 [1] and internationally at many scientific meetings over the world [2, 3, 4 ]. The result is a visual change in the buttock position to a higher one, which elongates the lower limbs and changes the proportions between lower and upper half of the body. The aim of this study is to describe a miniinvasive procedure of beautification of the buttock form without scars by creating a lifting effect on the buttock's subcutaneous tissue, using a suture that takes the inferiorly positioned deep fibrose tissue and fixes it upwards to the sacrocutaneous fascia, discovered by the author. Aesthetic and technical considerations required properly sculpting the buttocks into a higher position, demonstrating nicely rounded form. Preoperative shape is discussed and patient evaluations, operative techniques, postoperative management and results after 4 years of experience are emphasized. 1032 female patients, and 26 male patients aged 1862 years, with ptosis and cellulite on the buttocks were treated since 1993 on an outpatient basis by the "Serdev suture technique without visible scars". Important instrumentarium is a long, curved, elastic needle and Polycon semielastic Bulgarian antimicrobial polycaproamide long term (in 2 years) absorbable surgical threads Polycon, produced in Bulgaria. This operation has been performed either alone or after ultrasonic assisted liposculpture (UAL) that reduces the amount of fat and heaviness. All patients reported a high degree of satisfaction. A stable improvement in the buttock position and form was observed for the period described. In the postoperative period the complication rate was minimal and resolved in the first 45 days post operative period. The skin puncture in the perianal zone makes antibiotic prophylaxis obligatory as well as a strict follow up for the first 7 days. Some pain in the sitting position was observed for at least 5 to 10 days, but all other social and professional duties and activities were possible. This outpatient procedure is effective in the correction of buttock laxity and ptosis and creates a new form, universally accepted as "happy buttocks"., Nikolay P. Serdev, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
668. Transientní monoklonální gamapatie – kazuistiky
- Creator:
- Spáčilová, Jana, Šolcová, L., and Tichý, Miloš
- Format:
- braille, text, and regular print
- Type:
- model:article, article, Text, kazuistiky, and TEXT
- Subject:
- monoklonální gamapatie nejistého významu, paraproteinémie--etiologie, imunoelektroforéza--metody--využití, lidé, ženské pohlaví, mužské pohlaví, lidé středního věku, and staří
- Language:
- Czech and English
- Description:
- Transientní monoklonální gamapatie je stav spojený s přechodnou přítomností monoklonálního imunoglobulinu v séru a/ nebo moči. V článku je popsáno několik kazuistik pozorování přechodné monoklonální gamapatie., Transient monoclonal gammopathy is state involved in present monoclonal immunoglobulin in serum and urine. In article is described several cases observation of transient monoclonal gammopathy., Spáčilová J., Šolcová L., Tichý M., and Literatura 4
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
669. Treffen auf neutralem Boden. Zu politischen Begegnungen im byzantinischen Mittelalter /
- Creator:
- Grünbart, Michael,
- Subject:
- diplomacie, politika zahraniční, zahraniční politika, mezinárodní vztahy, světové dějiny středověku (do r. 1492), and Byzanc
- Language:
- German and English
- Description:
- Meetings on neutral grounds. Remarks on political encounters in Byzantium.
- Rights:
- unknown
670. Treści konttreformacyjne późnobarokowej kazalnicy w kłodzkim kościele Jezuitów pw. Wniebowzięcia NMP /
- Creator:
- Stoklasek-Michalak, Joanna
- Subject:
- řád, jezuité, protireformace, umění barokní, kazatelny, kostely, ikonografie, světové dějiny 1648-1789, Polsko, teologie, ikonografie, zbožnost, hagiografie, and sochařství, sochaři, řezbářství
- Language:
- Polish and English
- Description:
- Counter Reformation Meaning of Late Barogue Pulpit in Jesuit Church of the Assumption of BVM in Kłodzko.
- Rights:
- unknown