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8851. Safety core approach for the system with high demands for a safety and reliability design in a partially dynamically reconfigurable field-programmable gate array (FPGA)

Creator:
Martin, Leso and Tomáš, Musil
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
Mass-parallel computing, neural networks, FPGA, Virtex-4, Safety Core, safety, reliability, and partial dynamic reconfiguration
Language:
English
Description:
This paper deals with a new approach to designing the micro-electronic system suitable for mass-parallel and neuronal structures realizations in which the high demand on safety and reliability is given. The presented concept is based on the FPGA platform. Authors point out various kinds of faults which can possibly occur during system cycle. Furthermore, authors introduce the Safety Core principle and define systems for which it is applicable. There are possibilities of using partial dynamic reconfiguration shown in this paper in the context of FPGA fabric testing, faults catching and correcting.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8852. Safety zones of quality during deep drawing of axis-symmetrical blanks

Creator:
Nikolov, Nikola and Baltov, Anguel
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
deep drawing, safety zones of quality, plastic strain localization, and stability of shape
Language:
English
Description:
A complex safety surface of the quality of deep drawn steel pieces is built on the basis of 45 numerical eperiments. This surface is a combination of subsurfaces reflecting the effects of plastic strain localization and stability loss of the form change of circular blanks. The safety zone of quality is disposed below the safety surface. Two parameters of quality are proposed. Their high values lead to dispositions of drawing forces out of the safety surface of quality and to disturbance of quality, respectively. The results obtained for the safety zone and reported in this paper give an opportunity of estimation in advance phenomena as plastic strain localization and stability loss during the blank form changes. The safety surface of quality is given and respective illustrative examples are presented. and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8853. Saliency analysis of Support Vector Machines for feature selection

Creator:
Tay, Francis E. H. and Cao, L. J.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
saliency analysis, feature selection, support vector machines, and structural risk minimization principle
Language:
English
Description:
This paper deals with the application of saliency analysis to Support Vector Machines (SVMs) for feature selection. The importance of feature is ranked by evaluating the sensitivity of the network output to the feature input in terms of the partial derivative. A systematic approach to remove irrelevant features based on the sensitivity is developed. Two simulated non-linear time series and five real financial time series are examined in the experiment. Based on the simulation results, it is shown that that saliency analysis is effective in SVMs for identifying important features.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8854. Salivary cortisol in low dose (1 μg) ACTH test in healthy women: comparison with serum cortisol

Creator:
Kateřina Šimůnková, Richard Hampl, Miroslav Hill, Jiří Doucha, Luboslav Stárka, and Karel Vondra
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, kortizol, physiology, cortisol, low dose ACTH test, salivary cortisol, total serum cortisol, transcortin, 14, and 612
Language:
English
Description:
To date, a single report has appeared on the use of salivary cortisol for adrenal function testing with a low dose ACTH, although 1 μg has become preferred as a more physiological stimulus than the commonly used 250 μg ACTH test. Our present study was aimed to obtain physiological data on changes of free salivary cortisol after 1 μg ACTH stimulation. This approach was compared with the common method based on the changes of total serum cortisol. Intravenous, low-dose ACTH test was performed in 15 healthy women (aged 22-40 years) with normal body weight, not using hormonal contraceptives, in the follicular phase of the menstrual cycle. Blood and saliva for determination of cortisol were collected before ACTH administration and 30 and 60 min after ACTH administration. Basal concentration of salivary cortisol (mean ± S.E.M., 15.9±1.96 nmol/l) increased after 1 μg ACTH to 29.1±2.01 nmol/l after 30 min, and to 27.4±2.15 nmol/l after 60 min. The differences between basal and stimulated values were highly significant (p<0.0001). The values of salivary cortisol displayed very little interindividual variability (p<0.04) in contrast to total serum cortisol values (p<0.0001) A comparison of areas under the curve (AUC) related to initial values indicated significantly higher AUC values for salivary cortisol than for total serum cortisol (1.89±0.88 vs. 1.22±0.19, p<0.01). Correlation analysis of serum and salivary cortisol levels showed a borderline relationship between basal levels (r=0.5183, p=0.0525); correlations after stimulation were not significant. Low-dose ACTH administration appeared as a sufficient stimulus for increasing salivary cortisol to a range considered as a normal adrenal functional reserve., K. Šimůnková, R. Hampl, M. Hill, J. Doucha, L. Stárka, K. Vondra., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8855. Sample d-copula of order m

Creator:
González-Barrios, José M. and Hernández-Cedillo, María M.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
d-copulas, fractal copulas, and sample d-copulas of order m
Language:
English
Description:
In this paper we analyze the construction of d-copulas including the ideas of Cuculescu and Theodorescu \cite{cucutheo}, Fredricks et al. \cite{frenero}, Mikusiński and Taylor \cite{mitay} and Trutschnig and Fernández-Sánchez \cite{trutfer}. Some of these methods use iterative procedures to construct copulas with fractal supports. The main part of this paper is given in Section 3, where we introduce the sample d-copula of order m with m≥2, the central idea is to use the above methodologies to construct a new copula based on a sample. The greatest advantage of the sample d-copula is the fact that it is already an approximating d-copula and that it is easily obtained. We will see that these new copulas provide a nice way to study multivariate data with an approximating copula which is simpler than the empirical multivariate copula, and that the empirical copula is the restriction to a grid of a sample d-copula of order n. These sample d-copulas can be used to make statistical inference about the distribution of the data, as shown in Section 3.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8856. Samuel compactification and uniform coreflection of nearness $\sigma$-frames

Creator:
Naidoo, Inderasan
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
$\sigma $-frame, nearness, and Samuel compactification
Language:
English
Description:
We introduce the structure of a nearness on a $\sigma $-frame and construct the coreflection of the category ${\mathbf N\sigma Frm}$ of nearness $\sigma $-frames to the category ${\mathbf KReg\sigma Frm}$ of compact regular $\sigma $-frames. This description of the Samuel compactification of a nearness $\sigma $-frame is in analogy to the construction by Baboolal and Ori for nearness frames in [1] and that of Walters for uniform $\sigma $-frames in [11]. We also construct the uniform coreflection of a nearness $\sigma $-frame, that is, the coreflection of the category of ${\mathbf N\sigma Frm}$ to the category U$\sigma $Frm of uniform $\sigma $-frames.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8858. Sand fly saliva: effects on host immune response and Leishmania transmission

Creator:
Rohoušová, Iva and Volf, Petr
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
Phlebotomus, Lutzomyia, sand fly saliva, leishmaniasis, and host immune response
Language:
English
Description:
The feeding success of sand flies (Diptera: Phlebotominae) is linked to the vast array of pharmacological substances in their saliva, which interferes with the host haemostasis and immune response. Modification of feeding site plays also an important role in Leishmania transmission. In naive hosts, co-inoculation of saliva and Leishmania parasites increases the chance of successful transmission. Disease exacerbation seems to be associated with enhanced production of type 2 cytokines and selective inhibition of some macrophage functions including the production of NO and H2O2. On the other hand, hosts repeatedly exposed to sand fly bites develop anti-saliva immune response that results in a protection against Leishmania infection. This led to a new interesting approach to anti-Leishmania vaccine - using salivary components to block parasite transmission. The review is therefore focused on the interactions that run between immunomodulatory molecules in sand fly saliva and host immune response, with the impact on Leishmania infection development. Recent studies revealed that saliva-based vaccine for leishmaniasis might be effective and feasible, however, several questions still require to be solved. The knowledge based on experimental mouse model cannot be fully extrapolated to dogs or humans and due to differences in salivary antigens between sand fly species the protective effect is species-specific. On the other hand, the specificity of salivary antigens enables the use of anti-saliva antibodies for monitoring the exposure of hosts to sand fly bites and might be used as a marker of risks for Leishmania transmission in endemic areas.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8860. Sarcopenia: monitoring, molecular mechanisms, and physical intervention

Creator:
Zembroń-Łacny, A., Driubek, W., Rogowski, Ł., Skorupka, E., and Dąbrowka, G.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, svaly, kryoterapie, muscles, cryotherapy, muscle aging, low-grade inflammation, resistance exercise, interval training, whole-body vibration, 14, and 612
Language:
English
Description:
According to European Working Group on Sarcopenia in Older People (EWGSOP) sarcopenia includes both a loss of muscle strength and a decline in functional quality in addition to the loss of muscle protein mass. In order to develop strategies to prevent and treat sarcopenia, the risk factors and causes of sarcopenia must be identified. Age-related muscle loss is characterized by the contribution of multiple factors, and there is growing evidence for a prominent role of low-grade chronic inflammation in sarcopenia. The elderly who are less physically active are more likely to have lower skeletal muscle mass and strength and are at increased risk of developing sarcopenia. Resistance training added to aerobic exercise or high-intensity interval training promote numerous changes in skeletal muscle, many of which may help to prevent or reverse sarcopenia. In this review, we provided current information on definition and monitoring, molecular mechanisms, and physical intervention to counteract sarcopenia., A. zembroń-Łacny, W. Dziubek, Ł. Rogowski, E. Skorupka, G. Dąbrowska., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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