The Hronov-Poříčí Trough represents the easternmost part of the Trutnov-Náchod Depression. The NW-SE striking structure was formed due to the post-Cretaceous flexural folding and is filled with the Upper Cretaceous sediments. Both the NE and SW margins of the trough are bounded by flexures with the Upper Cretaceous strata dipping 40-60° towards the axis of the trough. The NE flexure is situated close to the parallel Hronov-Poříčí Fault Zone. Up to now, it is not fully known, in what extent the normal faulting was involved in the evolution of the structure. From the geomorphological point of view, the normal fault constraints of the trough seem to be acceptable, as the surface topography of its present margins exhibit many signs typical for fault scarps. However, the existence of a fault system bounding all round the Hronov-Poříčí Trough has not b een proved by any geological research. Hence the geophysical research was carried out on both sides of the NW part of the trough to support one of these hypothesis. Five geoelectrical profiles were measured in the area and the fault system was proved on the NE side of the trough. On the SW boundary the fault system was not found. Thus it seems, that the NE boundary is controlled by fault tectonics, whereas the SW boundary is rather formed by a simple flexure., Jan Valenta, Vladimír Stejskal and Petra Štěpančíková., and Obsahuje bibliografické odkazy
Permeability plays an important role in the field of geotechnical engineering. Under high temperature and high pressure condition, the physical-chemical and structure properties (such as decomposition, oxidation, dehydration, evaporation, phase transition etc.) of rock have obviously changing, which are significant affected the rock permeability. In order to analyze the influence of temperature and confining pressure on the permeability of rock (sandstones, siltstones and conglomerates) data for permeability was obtained from the literature. The results indicate that temperature and confining pressure have great influence on the permeability of rock, especially for sandstone. There is a threshold temperature and when the heating temperature is lower than the threshold temperature, the permeability of sandstone gradually increases with an increase in temperature. When the heating temperature is higher than 300 ºC (especially 400 ºC), the permeability rapidly increases. The permeability of sandstone decreases gradually with the confining pressure increases. This study of the relationship between rock permeability and temperature and confining pressure lays a foundation for investigations of multi-disciplinary issues regarding high temperatures and high pressures and it can be used for the study of petroleum storage and safe nuclear waste disposal., Zhenlong Ge, Qiang Sun and Wenping Li., and Obsahuje bibliografii
In the frame of advanced studies of coal structure the temperature conditions of coal origin were investigated through thermal stability of aluminum complexes in coal substance. These compounds were discovered by solid-state nuclear magnetic resonance measurements of 27Al as a part of coal substance closely bonded to organic mass of coal. In obtained spectra, Al-hexaphenoxide and Al-tetrahydroxy-diphenoxide complexes were identified. These complexes were further prepared and their thermal stability tested by thermal analysis method. It was found that a) they can originate under room temperature and atmospheric pressure and b) they are thermally stable only up to approximately 85 or 95 °C. As both Al-hexaphenoxide and Al-tetrahydroxy-diphenoxide complexes are the integrated constituents of coal substance it can be deduced that, in the beginning, coal was formed under very mild thermal conditions. As investigated materials, coals and clays from the Czech basins and gagatite from Poland were measured., Pavel Straka and Jana Náhunková., and Obsahuje bibliografii
Whole blood surface tension of 15 healthy subjects recorded by the ring method was investigated in the temperature range from 20 to 40 °C. The surface tension σ as a function of temperature t (°C) is described by an equation of linear regression as σ(t) = (-0.473 t + 70.105) × 10-3 N/m. Blood serum surface tension in the range from 20 to 40 °C is described by linear regression equation σ(t) = (-0.368 t + 66.072) × 10-3 N/m and linear regression function of blood sediment surface tension is σ(t) = (-0.423 t + 67.223) ×10-3 N/m., J. Rosina, E. Kvašňák, D. Šuta, H. Kolářová, J. Málek, L. Krajči., and Obsahuje bibliografii
This paper focuses on the impact of changes in temperature on one bay of St Vitus’ Cathedral in Prague Castle. The objective of the study is to simulate as correctly as possible the distribution of temperatures in the structure, and then to compute the thermal dilatation movements. Theoretical simulation of dilatation movements involves simulating the temperatures in the structure and then computing the displacements. Insolation and changes in air temperature around the structure are included in the temperature simulation. The computed temperature fields are used as a loading for computing the forces and deformations of one bay of St Vitus’ Cathedral. The theoretical deformation values obtained by means of the 3-D finite element model were compared with the measurements. The computed surface temperatures were also confronted with the surface temperatures measured in the interior and on the exterior of the cathedral. The results obtained from the simulations correspond well with the measured surface temperatures and deformations., Pavel Beran, Jiří Máca and Petr Fajman., and Obsahuje bibliografii
Obstructive sleep apnea (OSA) has been demonstrated to be
implicated in disorder of insulin secretion and diabetes mellitus.
In this study, we aimed to evaluate the protective role of tempol,
a powerful antioxidant, in chronic intermittent hypoxia
(IH)-induced pancreatic injury. The rat model of OSA was
established by IH exposure. The pathological changes, increased
blood-glucose level, and raised proinsulin/insulin ratio in
pancreatic tissues of rats received IH were effectively relieved
by tempol delivery. In addition, the enhanced levels of
pro-inflammatory cytokines, TNF-α, IL-1β, IL-6, and inflammatory
mediators, PGE2, cyclooxygenase-2 (COX-2), NO, and inducible
nitric oxide synthase (iNOS) in pancreatic tissue were suppressed
by tempol. Moreover, tempol inhibited IH-induced apoptosis in
pancreatic tissue as evidenced by upregulated Bcl-2 level, and
downregulated Bax and cleaved caspase-3 levels. Finally, the
abnormal activation of mitogen-activated protein kinase (MAPK)
and nuclear factor kappa-light-chain-enhancer of activated B cells
(NF-κB) signaling pathways induced by IH was restrained by
tempol administration. In summary, our study demonstrates that
tempol relieves IH-induced pancreatic injury by inhibiting
inflammatory response and apoptosis, which provides theoretical
basis for tempol as an effective treatment for OSA-induced
pancreatic injury.
Glochidia are the larval stage of freshwater unionid mussels that parasitize the fins and gill apparatus of fish. A total of 22 fish species were examined for the presence of glochidia whose distribution on individual hosts was studied on three common fish species, the roach Rutilus rutilus (L.), perch Perca fluviatilis L. and bitterling Rhodeus sericeus (Pallas). Between 1997 and 1999, the fish were obtained from the rivers Morava and Kyjovka and surrounding water pools in the Czech Republic. The glochidia of two genera, Unio and Anodonta, were found. Anodonta glochidia were observed on 10 fish species, Unio glochidia on 17 fish species. There was a difference in spatial distribution of glochidia on the body of the host fish. Unio glochidia were predominantly located on the gills, whereas most Anodonta glochidia were found on the fins, with the highest numbers of glochidia were observed on the margin of the pectoral fins. For the gill apparatus, Unio glochidia were found predominantly on the second and third arch. Anodonta glochidia were predominantly found during winter and spring (November-May), whereas Unio glochidia were more abundant during May and June. The number of glochidia was positively correlated with fish length in perch highly infected by Anodonta glochidia and perch infected by Unio glochidia. Of the three fish species, the highest occurrence of parasites was found on perch with fewer observed on roach. In spite of the close relationship between bitterling and unionid mussels, glochidiosis was rare on this fish species.
The first trimester of pregnancy is characterized by continuous proliferation, invasion and differentiation of cytotrophoblasts. These processes are precisely controlled both, in space and time by molecules such as endothelin-1 (ET-1). ET-1 is expressed in human first trimester trophoblast and is known to stimulate cytotrophoblast proliferation through endothelin A and B receptor subtypes (ETA and ETB), and cytotrophoblast invasion through ETB. However, temporal changes of the ET system during the first trimester of pregnancy have not been previously studied. This study tested the hypothesis that ET-1 release, ETA and ETB expression are increased towards the end of the first trimester of pregnancy (weeks 10-12 vs. weeks 6-9), resulting in increased cytotrophoblast proliferation and invasion. Tissue samples were obtained from 17 surgical pregnancy interruptions (week 6-9: n=9; week 10-12: n=8). After cytotrophoblast isolation, the invasive and proliferative phenotypes were immune-separated by an α6-integrin antibody. Both proliferative and invasive cytotrophoblasts were cultured separately on plastic or Matrigel for 24 h. ET-1 release into the culture medium of both cytotrophoblast subtypes was measured by radioimmunoassay. ETA and ETB mRNA expression was measured by RT-PCR, and the ET-1 effect on cytotrophoblast proliferation and invasion was determined using proliferation and invasion assays, respectively. ET-1 release increased from early to late first trimester of pregnancy in both proliferative (1.8-4.5 fold) and invasive cytotrophoblasts (9.3-28 fold), especially when cultured on Matrigel. This was paralleled by less ETB mRNA on invasive cytotrophoblasts independent of the time period in first trimester, whereas ETA expression was similar on proliferative an invasive cytotrophoblasts. Proliferation and invasion of cytotrophoblasts under control conditions decreased from early to late first trimester. The ET-1/ET-receptor system changes between weeks 6-9 and 10-12 in pregnancy. Our data suggest an autocrine and endocrine ET-1 effect, which is stronger in late than in early first trimester of pregnancy paralleled by different stimulatory effects on trophoblast invasion and proliferation. In general, this suggests time as an additional effector of the critical processes governing placental development in the first trimester of human pregnancy., A. Majali-Martinez, S. Barth, U. Lang, G. Desoye, M. Cervar-Zivkovic., and Seznam literatury
This essay examines, in ten clearly formulated propositions, the causes and the long-term impact of the Munich Agreement of September 1938. This complex theme is approached through not purely national lenses. The term ''betrayal'' as a dominant label of the actions of the two West European democratic powers is thus questioned. The author claims that the British and French unwillingness to go to war because of Czechoslovakia’s border regions is, in the light of previous historical developments, understandable and, in a way, even rational. He also points out certain defi ciencies in the Czechoslovak treatment of its German minority. At the same time, Czechoslovakia’s political leaders were playing a strange game with their people in September 1938, alternately stirring up and moderating their patriotic feelings - depending on where the behind-the-scenes negotiations on Czechoslovak border regions were heading at a given moment. Also the alleged Soviet preparedness to come to Czechoslovakia’s assistance in September 1938 is more than questionable; Stalin intended to intervene only in a European war, not to help lonesome Czechoslovakia. Nonetheless, Munich has had, and unfortunately continues to have, a fundamental infl uence on the Czech ''mental map'' of Europe. The lesson according to which the West should not be trusted and it would therefore be advisable to look for protection and alliance in the East still lives on in minds of a number of Czech politicians and of a not negligible segment of the public. On the other hand, the ''lessons of Munich,'' according to which it is not advisable to make concessions to any aggression or blackmailing, became a part of policies of Western statesmen confronting expansionist dictatorships, and the other life of Munich thus continued to complicate the use of ''negotiations'' as a method of dealing with international crises by Western politicians in the Cold War and beyond. and Přeložil Jiří Mareš