Czech White-Nose Syndrome Team together with international collaborators discovered mechanisms of tolerance that protect Palearctic bats from white-nose syndrome (WNS), the disease that caused mass die-off in North America. The discovery raises hope for a better future of bats in North American ecosystems. White-nose syndrome (WNS) is caused by a generalist pathogen Pseudogymnoascus destructans with the worst possible characteristics of an infectious fungal agent. The generalist nature of the WNS fungus means that it can infect any bat hibernating in a contaminated cave or mine and, moreover, it may remain viable and virulent, waiting for its hosts until the next hibernation period. Harmless to humans, the WNS fungus kills hibernating North American bats in winter. However, loss of voracious insectivorous bats from agricultural ecosystems may result in economic costs required for increased pest control. Without mass die-offs of bats harbouring the WNS agent in Europe, the response to disease is an enigma. To study the survival crossroads, the Czech WNS Team focused on the relationship between pathogen quantity and disease under natural conditions. High disease prevalence together with high fungal loads in absence of bat population declines in Eurasia indicates disease tolerance mechanisms, where hosts limit harm inflicted by the pathogen but do not hinder its growth. The tolerance mechanisms revealed by the Czech WNS Team is a function of bat adaptation to the presence of the pathogen. and Natália Martínková.
Here we analyzed associations between muscles mass, total bone mineral content (BMC), lumbar spine bone density (BMD L1-L4) and serum or urine hormones in healthy peripubertal girls. Total BMC and areal BMD L1-L4, muscle mass and fat were measured by dual-energy X-ray absorptiometry (DXA). Muscle force (N) was estimated by a dynamometer. Circulating estradiol, folliclestimulating hormone (FSH), luteinizing hormone (LH), 25-hydroxy vitamin D, parathyroid hormone (PTH), insulin-like growth factor 1 (IGF-1), leptin, osteocalcin, bone isoenzyme of alkaline phosphatase (bALP) and total calcium and phosphorus were quantified as the nocturnal melatonin and serotonin urinary excretion. Partial correlations adjusted for height, Tanner score and physical activity confirmed positive relationships between BMC or BMD L1-L4 (Z-score) and lean mass or fat. Furthermore, positive relationship was observed between BMC or BMD L1-L4 (Z-score) and serum leptin. After adjustment for Tanner score and physical activity, positive associations were observed between lean mass and IGF-1, leptin levels or muscle force. We proved positive relationships between bone mass and serum leptin in peripubertal girls., V. Cirmanova, I. Zofkova, P. Kasalicky, V. Lanska, M. Bayer, L. Starka, R. Kanceva., and Obsahuje bibliografii