Since October 2011, the Russian GLObal NAvigation Satellite System (GLONASS) has been revitalized and is now fully operational with 24 satellites in orbit. It is critical to assess the benefits and problems of using GLONASS observations (i.e. GLONASS-only or combined Global Positioning System (GPS) and GLONASS) for precise positioning and zenith total delay (ZTD) retrieval on a global scale using precise point positioning (PPP) technique. In this contribution, extensive evaluations are conducted with Global Navigation Satellite System (GNSS) data sets collected from 251 globally distributed stations of the International GNSS Service (IGS) network in July 2016. The stations are divided into 30 groups by antenna/radome types to investigate whether there are ante nna/radome-dependent biases in position and ZTD derived from GLONASS-only PPP. The positioning results do not show obvious antenna/radome-dependent biases except the stations with JAV_RINGANT_G3T/NONE. For these stations, the averaged biases in horizontal component, especially in the north component, can achieve as high as -9.0 mm. The standard de viation (STD) and root mean square (RMS) are used as indicators of positioning repeatability and accuracy, respectively. The averaged horizontal STD and RMS of GLONASS-only PPP are comparable to GPS-only PPP, while in vertical component, those for GLONASS-only P PP are larger. Furthermore, the STD and RMS of GPS+GLONASS combined PPP solutions are the smallest in horizontal and vertical components, indicating that adding GLONASS observations can achieve better positioning performance than GPS-only PPP. With the IGS final ZTD as reference, we find that ZTD biases and accuracy of GLONASS-only are latitude - and antenna/radome-independent. The ZTD accuracy of GLONASS-only PPP is slightly worse than that of GPS-only PPP. Compared with GPS-only PPP, the ZTD accuracy is only improved by 1.3% from 7.8 to 7.7 mm by adding GLONASS observations., Feng Zhou, Shengfeng Gu, Wen Chen and Danan Dong., and Obsahuje bibliografické odkazy
This study extends our previous work by examining the effects of alpha2 -adrenoceptors under cold stimulation involving the increase of myogenic vascular oscillations as increases of very-low-frequency and low-frequency of the blood pressure variab ility. Forty-eight adult male Sprague-Dawley rats were randomly divided into four groups: vehicle; yohimbine; hexamethonium+yohimbine; guanethidine+yohimbine. Systolic blood pressure, heart rate, power spectral analysis of spontaneous blood pressure and he art rate variability and spectral coherence at very-low-frequency (0.02 to 0.2 Hz), low-frequency (0.2 to 0.6 Hz), and high-frequency (0.6 to 3.0 Hz) regions were monitored using telemetry. Key findings are as follows: 1) Cooling-induced pressor response was attenuated by yohimbine and further attenuated by hexamethonium+yohimbine and guanethidine+yohimbine, 2) Cooling-induced tachycardia response of yohimbine was attenuated by hexame - thonium+yohimbine and guanethidine+yohimbine, 3) Different patterns of p ower spectrum reaction and coherence value compared hexamethonium+yohimbine and guanethi-dine+yohimbine to yohimbine alone under cold stimulation. The results suggest that sympathetic activation of the postsynaptic alpha2-adrenoceptors causes vasoconstriction and heightening myogenic vascular oscillations, in turn, may increase blood flow to prevent tissue damage under stressful cooling challenge., Y.-H. Lin, Y.-P. Liu, Y.-C. Lin, P.-L. Lee, C.-S. Tung., and Obsahuje bibliografii
Příspěvek Martina Ledvinky je zprávou o muzikologické konferenci studentů Ústavu hudební vědy FF UK, která se uskutečnila v prostorách Kabinetu hudební historie EÚ AV ČR dne 24. května 2012., Martin Ledvinka., Rubrika: Konference, and Cizojazyčné resumé není.
At frog neuromuscular junction, noradrenaline (NA) shortens the release period for evoked quantal release acting on a b 1 receptor. To test the hypothesis that this action of NA is mediated by cAMP, we measured the latencies of focally recorded uni-quantal endplate currents (EPCs) after application of dibutyryl-cAMP (db-cAMP) and adenylyl cyclase activator, forskolin. The interval between the time when responses with minimal delay appeared and the point at which 90 % of all latencies had occurred (P90 parameter) was shortened in the presence of both 1x10-6 mol/l db-cAMP and 1x10-6 mol/l forskolin by about 30 %. The cAMP-induced shortening is equal to that found after application of NA and effects of both drugs are not additive., E. Bukcharaeva, D. Samigullin, E. E. Nikolsky, F. Vyskočil., and Obsahuje bibliografii
Within the framework of our studies on hypertension in various rat strains, we have examined the effect of cyclosporin A (CsA) on intracellular calcium signaling under conditions of oxidative stress. For these preliminary experiments, we have chosen isolated hepatocytes of normotensive rats as a model system for the study of the role of intracellular calcium. We used tert-butyl hydroperoxide (t-BHP, 1 mmol.l-1) as an prooxidant agent. When compared to the controls, we found increased levels of cytosolic free calcium concentration (Ca2+i) during 120 min incubation. The preincubation of hepatocytes with CsA in the concentration of 0.5 m mol.l-1 did not change the physiological level of cytosolic calcium. However, a dual action of CsA on elevated Ca2+i was observed during oxidative injury of hepatocytes: while in the first period of incubation CsA increased Ca2+i, CsA reduced the effect of t-BHP on Ca2+i during the next period of incubation. This indicates the ability of CsA to modify oxidative stress, but further studies are necessary to explain these findings., E. Kmoníčková, L. Kameníková, S. Hynie, H. Farghali., and Obsahuje bibliografii
The Institute of the Rock Structure and Mechanics AS CR operates the GEONAS network that now consists of 17 perm anent GPS observatories. The outliers and in consistencies occur within the time series observed in the winter season 200 5/2006 for the position of the GNSS antennas of the observatories SNEC and BISK located high in the m ountains, at th e Sněžka Mt. (1602 m, the Giant Mts.) and the Biskupská kupa Mt. (890 m, the Jeseníky Mts.) respectively. Therefore web cameras and meteorological sensors were in stalled at GEONAS observatories located in the mountain regions. The snow coverage and other meteorological influences affecti ng the antennas monitoring GPS signals at these observatories were estimated. The individual photos were analyzed and compared to variations in the time series to obtain the time series for winter seasons reducing the snow coverage effects., Milada Grácová, František Mantlík, Vladimír Schenk and Zdeňka Schenková., and Obsahuje bibliografické odkazy
Mitochondrial dysfunction and oxidative stress participate in the development of diabetic complications, however, the mechanisms of their origin are not entirely clear. Coenzyme Q has an important function in mitochondrial bioenergetics and is also a powerful antioxidant. Coenzyme Q (CoQ) regenerates alpha-tocopherol to its active form and prevents atherogenesis by protecting low-density lipoproteins against oxidation. The aim of this study was to ascertain whether the experimentally induced diabetes mellitus is associated with changes in the content of endogenous antioxidants (alpha-tocopherol, coenzymes Q9 and Q10) and in the intensity of lipoperoxidation. These biochemical parameters were investigated in the blood and in the isolated heart and liver mitochondria. Diabetes was induced in male Wistar rats by a single intravenous injection of streptozotocin (45 mg.kg-1), insulin was administered once a day for 8 weeks (6 U.kg-1). The concentrations of glucose, cholesterol, alpha-tocopherol and CoQ homologues in the blood of the diabetic rats were increased. The CoQ9/cholesterol ratio was reduced. In heart and liver mitochondria of the diabetic rats we found an increased concentration of alpha-tocopherol, however, the concentrations of CoQ9 and CoQ10 were decreased. The formation of malondialdehyde was enhanced in the plasma and heart mitochondria. The results have demonstrated that experimental diabetes is associated with increased lipoperoxidation, in spite of the increased blood concentrations of antioxidants alpha-tocopherol and CoQ. These changes may be associated with disturbances of lipid metabolism in diabetic rats. An important finding is that heart and liver mitochondria from the diabetic rats contain less CoQ9 and CoQ10 in comparison with the controls. We suppose that the deficit of coenzyme Q can participate in disturbances of mitochondrial energy metabolism of diabetic animals., J. Kucharská, Z. Braunová, O. Uličná, L. Zlatoš, A. Gvozdjáková., and Obsahuje bibliografii
Stáří a stárnutí jedinců jsou bezpochyby fenomény, které zaujímaly významné místo ve společnosti již v dobách dávno minulých. Během 20. století však nabrala otázka stárnutí nového rozměru, neboť začala nově přesahovat z úrovně individuální na úroveň celospolečenskou. V důsledku zlepšování některých společenských podmínek (např. lékařské péče, životního stylu, hygieny, životní úrovně atd.), jež bylo nastartováno již zhruba na počátku 19. století, dochází k odsouvání úmrtí do vyšších věků, a lidé tak žijí déle. V moderních společnostech je tento jev obvykle doprovázen poklesem porodnosti a plodnosti. Kombinace těchto dvou faktorů pak ve svém konečném důsledku způsobuje proces, který nazýváme demografickým stárnutím. Obecně je tedy třeba rozlišovat dva pohledy na problematiku stárnutí. První pohled se zaměřuje na tzv. stárnutí individuální, druhý přístup se zabývá demografickým stárnutím lidských populací, ovšem je zřejmé, že obě dvě hlediska jsou mezi sebou navzájem provázaná. Podobně tomu bude i v následujícímpříspěvku, jenž se bude zabývat nejen přehledem problematiky demografického stárnutí, ale dotkne se také otázek o dlouhověkosti a kvalitě života, které se dostávají do popředí v souvislosti s tematikou stárnutí jednotlivců., Old age and aging of individuals are phenomenons that took important place in society as early as former times. During twentieth century the question of aging got new meaning, because it newly started to overreach from individual level to all-society. As a result of improvement of some social conditions (f.e. medical care, lifestyle, hygiene, living standard etc.), that was already initiated approximately at the beginning of the nineteenth century, dying started to be moved to higher age and people live longer. In modern societies this event usually goes with decline of natality and fertility. In final effect combination of these two factors causes the process that is known as demographic aging. In general we have to distinction between two views of problems of aging. The first view is focused on individual aging, the second one on demographic aging of human population. But it is clear that both of these views relate to each other. Similarly this article offers the roundup of problems of demographic aging, but also gives a touch of questions about longevity and quality of life, that gain ground in connection with theme of individual aging., Michaela Dimitrová., and Seznam literatury
We estimated the common seasonal signal (annual oscillation) included in the Global Positioning System (GPS) vertical position time series by using Multichannel Singular Spectrum Analysis (MSSA). We employed time series from 24 International GNSS Service (IGS) stations located in Europe which contributed to the newest ITRF 2014 (International Terrestrial Reference Frame). The MSSA method has an advantage over the traditional modelling of seasonal signals by the Least-Squares Estimation (LSE) and Singular Spectrum Analysis (SSA) approaches because it can extract time-varying and common seasonal oscillations for stations located in the considered area. Having estimated the annual curve with LSE, we may make a misfit of 3 mm when a peak-to-peak variations of seasonal si gnals are to be estimated due to the time-variability of seasonal signal. A variance of data modelled as annual signal with SSA and MSSA differs of 3 % at average what proves that the MSSA-curves contain only time-varying and common seasonal signal and leave the station-specific part, local phenomena and power-law noise intact. In contrast to MSSA, these effects are modelled by SSA. The differences in spectral indices of power-law noise between MSSA and LSE esti mated with Maximum Likelihood Estimation (MLE) are closer to zero than the ones between SSA and LSE, which means that MSSA curves do not contain site-specific noise as much as the SSA curves do., Marta Gruszczynska, Anna Klos, Severine Rosat and Janusz Bogusz., and Obsahuje bibliografické odkazy