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62. Effectivenes of spironolacton in complex therapy of rheumatoid arthritis
- Creator:
- Komarova, Elena and Rebrov, Borys
- Format:
- electronic, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, srovnávací studie, and TEXT
- Subject:
- revmatoidní artritida--diagnóza--etiologie--farmakoterapie, antagonisté mineralokortikoidních receptorů--terapeutické užití, spironolakton--terapeutické užití, výsledek terapie, kvalita života, cytokiny--účinky léků, kohortové studie, statistika jako téma, dospělí, ženské pohlaví, lidé, mužské pohlaví, and lidé středního věku
- Language:
- English
- Description:
- Aldosterone blocker Spironolactone has antiinflammatory, antiproliferative and antioxidative effects, that is why pathogenetically it is expedient to use it in complex therapy of rheumatoid arthritis. Material and methods: 46 patients with RA took 2550 mg/day of Spironolactone during 12 months as an addition to standard therapy, the comparison group consisted of 47 patients that got only standard therapy, all the patients were fully examined prior and post the treatment. Results: complex RA therapy leads to improved VAS, HAQ, the antioxidative potential index F; decreased blood concentrations of TNFα, ICAM1, FGF and VEGF in contrast to standard therapy. Complex therapy made reduced the DAS 28 more > 0.6. Conclusions: applying of Spironolactone in complex therapy of rheumatoid arthritis contributes to more pronounced improvement in indices of articular syndrome and patients life quality, reduce of antiinflammatory, antiproliferative and angiogenic cytokines, and more effectively reduces the activity of the disease comparing to standard therapy., Elena Komarova, Borys Rebrov, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
63. Efficient collective redress mechanisms in Visegrad 4 Countries: an achievable target?
- Creator:
- Simon, Rita and Müllerová, Hana
- Publisher:
- Ústav státu a práva AV ČR, v.v.i
- Format:
- electronic, electronic resource, remote, bez média, online zdroj, and 1 online zdroj (280 stran).
- Type:
- model:monograph and TEXT
- Subject:
- Soukromé právo, náhrada škody, reparations, země Visegrádské skupiny, Visegrád Group countries, kolektivní odškodnění, collective redress, 347.426.6, 347.513, (4-191.2), (082), (0.034.2:08), 16, and 347
- Language:
- English
- Description:
- Rita Simon, Hana Müllerová (eds.)., Obsahuje bibliografii a bibliografické odkazy, and born digital
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
64. Elastografická charakteristika jazvy po cisárskom reze v priebehu 6 mesiacov po cisárskom reze
- Creator:
- Dosedla, Erik and Calda, Pavel
- Format:
- electronic, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, abstrakt z konference, and TEXT
- Language:
- Czech and Slovak
- Description:
- Erik Dosedla, Pavel Calda
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
65. Elektronický sborník příspěvků multioborové konference LASER62: hotel Galant, Lednice, 9.-11. listopad 2022
- Creator:
- Růžička, Bohdan
- Publisher:
- Ústav přístrojové techniky AV ČR,v.v.i.
- Format:
- electronic, electronic resource, remote, bez média, online zdroj, and 87 stran : ilustrace, tabulky, grafy.
- Type:
- model:monograph and TEXT
- Subject:
- Elektrotechnika, lasery, mezioborový kontext, lasers, interdisciplinary context, 621.375.826, 681.7.069.24, 535.8, 001.2, (062.534), (0.034.2:08), 19, and 621.3
- Language:
- Czech, English, and Slovak
- Description:
- editor: Bohdan Růžička., Obsahuje bibliografie, České, anglické a slovenské příspěvky, and born digital
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
66. Enhancing Research Competences in Healthcare Higher Education
- Creator:
- Sirkka, Andrew and Čáp, Juraj
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, práce podpořená grantem, and TEXT
- Subject:
- průzkumy a dotazníky, lékařská praxe založená na důkazech, výzkumný projekt, lidé, and studium lékařství
- Language:
- Czech and English
- Description:
- Background: In evidence-based education, experts are supposed to possess skills and content knowledge. Scientific skills provide the tools and ways of thinking that enable researches to build the robust conceptual frameworks needed to gain expertise. Science education should not only provide broad content knowledge base but also develop analytical thinking, understanding of scientific research processes, and inspire curiosity of researchers. Objectives: is paper discusses the key results of subjective evaluation of attained outcomes of a 2,5-year project focused on enhancing research competences in a faculty of health sciences. Methods: e data was gathered from project members by four consequent semi-structured online questionnaires. Total number of respondents was 78 (N = 78) with 75% response rate. e data was analysed by a summative content analysis combining quantitative and qualitative analyses. Results: e findings present evident progress in personal achievements, team working, and scientific practice in the faculty. Based on identified needs the concrete measures supported learning and lead to enhancement in the target group’s research competences. Conclusions: Capacity building approach was successful in laying a robust foundation for consistent development in research-based practice both in academic and professional levels. Further research should be conducted on the long-term impacts of the project in the faculty. and Andrew Sirkka, Juraj Čáp
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
67. Epigenetika a chybějící dědičnost
- Creator:
- Petr, Jaroslav
- Format:
- 115-119, electronic, electronic resource, and remote
- Type:
- model:article, article, Text, and TEXT
- Language:
- Czech and English
- Description:
- Nejlepší definice epigenetiky říká, že se zabývá studiem vlastností, jež jsou předávány prostřednictvím meiózy nebo mitózy a přitom nejsou závislé na primární struktuře DNA Britský genetik Adrian Bird k tomu dodává: „Epigenetika je užitečný termín, pokud nevíte, o co jde. Pokud to víte, nazvete to úplně jinak“ (Anonymus 2010)., The best working definition for the epigenetics is that it is the study of traits heritable through meiosis or mitosis that are not dependent on the primary DNA sequence. Even so, British geneticist Adrian Bird has commented: “Epigenetics is useful word if you don’t know what’s going on – if you do, you use something else” (Anonymus 2010)., and Jaroslav Petr
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
68. Erythrocyte blood group antigens and alterations of the hormonal status among the reproductive age women with breast tumors
- Creator:
- Nakashidze, Irina, Kotrikadze, Nanuli, Diasamidze, Anzor, Nagervadze, Marina, Alibegashvili, Manana, Ramishvili, Liana, and Gordeziani, Manana
- Format:
- electronic, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, and TEXT
- Subject:
- krevní skupiny - systém ABO--imunologie--krev, krevní skupiny - systém Rh-Hr--imunologie--krev, nádory prsu--imunologie--krev--patofyziologie, pohlavní steroidní hormony--krev, tyreoidální hormony--krev, prolaktin--krev, nádorové procesy, dospělí, ženské pohlaví, lidé, lidé středního věku, and kohortové studie
- Language:
- English
- Description:
- The significance of ABO blood system groups antigens in development of some malignant tumors is already established. The alteration of hormonal homeostasis must also be taken into account. Hence the aim of the investigation was to study ABO and Rh blood system antigens and hormonal status among reproductive age women with benign and malignant breast tumors. Methods: The determination of hormones was made by the enzymatic analysis method (ELAIZA), provided by proper ELAIZA kits. For the study of ABO and RhHr system antigens, internationally recognized immunoserology methods were used. Results: High index of the breast gland tumors were revealed in patients with A(II) phenotypic group, according to the ABO system. The frequency distribution of O(I) phenotypic group was low among women with breast tumors. Among D, C, E, c and e antigens of the Rh system, the frequency of D and E antigens were increased in benign and malignant breast tumors patients. The study of hormonal balance revealed thyroid gland hypofunction and increased level of estradiol on the background of increased testosterone and decreased progesterone levels. Such hormonal imbalance and excess production of estradiol creates conditions for malignant tumor formation in reproductive age women. Conclusion: The highest frequency of breast cancer in reproductive age was revealed in A(II) group patients. The wide spectrum of hormonal disorders were revealed in breast tumor patients of the reproductive age, which was especially clear in cases of malignant tumor., Irina Nakashidze, Nanuli Kotrikadze, Anzor Diasamidze, Marina Nagervadze, Manana Alibegashvili, Liana Ramishvili, Manana Gordeziani, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
69. Essential oil of calendula officinalis
- Creator:
- Juraeva, Aziza, Azizov, Olim, Abdullabekova, Viloyat, and Yunusxodjaeva, Nodira
- Format:
- electronic, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, and TEXT
- Subject:
- Calendula, oleje prchavé--farmakologie--chemie, seskviterpeny--analýza, and fytoterapie
- Language:
- English
- Description:
- The article presents the results of research into component composition of raw calendula’s essential oil. The study was conducted by gas chromatography mass spectrophotometry method under the following conditions: column - CP- Wax58FFAPCB 24,5 mm x 250 mm x 0,20 mm nominal, the mobile-phase-He (helium), speed-column mobile phase -1.0 ml /min, volume sample injection - 5 mkl; resolutions (5:1), in the Split, high-boiling chamber -220°C, detector temperature 275°C; Aux-200°C, column temperature 70°C gradually increased from 10°C / min to 250°C, maintained to the end of analysis temperature regime (250°C) for 5 min. muurololnaftalenol-8.522%. In addition, it was ascertained that in different parts of the world calendula’s essential oils differ from each other in qualitative composition and quantitative components., Aziza Juraeva, Olim Azizov, Viloyat Abdullabekova, Nodira Yunusxodjaeva, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
70. Evaluační praxe v podpoře zdraví: teoretický rámec pro analýzu
- Creator:
- Tušková, Eva
- Format:
- 14-20, electronic, electronic resource, and remote
- Type:
- model:article, article, Text, práce podpořená grantem, and TEXT
- Subject:
- programy podpory zdraví--metody--organizace a řízení, politika zdravotní - programy--organizace a řízení, vládní programy, hodnotící studie jako téma, hodnocení programu, and lidé
- Language:
- Czech and English
- Description:
- Hodnocení a sledování průběhu veřejně politických opatření (včetně politiky podpory zdraví) je, zejména v rámci diskurzu na poli veřejné politiky jako vědní disciplíny, chápáno jako nedílná součást tvorby a realizace veřejné politiky, která by měla přispívat k naplňování demokratických principů ve veřejné správě. Vlastní evaluační praxe, a tedy i konečný smysl hodnocení, se však může značně lišit od odborných akademických metodologických doporučení a deklarací v rámci strategických veřejně politických dokumentů. Cílem předkládaného článku je na základě systematické rešerše vytvořit teoretický rámec pro exploraci a porozumění evaluační praxi v politice podpory zdraví na národní úrovni (včetně podmínek, které na ni mohou působit) a představit zjištění některých zahraničních autorů, kteří zkoumali jednotlivé případy evaluační praxe., Public policy (including health promotion policy) evaluation and monitoring is considered, especially in the discourse on the ground of public policy as an academic discipline, to be an integral part of public policy creation and implementation, which should contribute to promotion of democratic principles in public administration. The particular evaluation practice and hence the very meaning of evaluation, may differ greatly from academic methodological recommendations and declarations included in strategic public policy documents. The aim of the article is to create a theoretical framework which can be used for exploration and understanding of evaluation practice in the health promotion policy at the national level (including various conditions which can influence the evaluation practice) and introduce some of the findings of authors dealing with particular cases of evaluation practice., and Eva Tušková
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public